| Clinical, radiologic, and therapeutic analysis of 14 patients with transverse myelitis associated with antiphospholipid syndrome: report of 4 cases and review of the literature. | |
| | |
MedLine Citation:
|
PMID: 20701956 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
OBJECTIVE: To analyze the clinical, radiologic, therapeutic, and developmental characteristics of transverse myelitis (TM) and antiphospholipid syndrome (APS). METHODS: We systematically searched English, Spanish, and Japanese articles on the subjects of TM and APS that had English abstracts in PubMed from 1966 to 2010. In addition, we reported on 4 patients with APS and TM that were treated by the Rheumatology Division of the Hospital das Clínicas da Faculdade de Medicina da Universidade in São Paulo, Brazil. RESULTS: Fourteen cases of patients with APS and TM were reviewed. The age of these patients ranged from 8 to 83, and cases of TM predominantly occurred among patients with primary APS (9/14). The clinical presentation of TM was characterized by effects on the thoracic spinal cord (9/14) that were associated with sphincter disturbances (8/14). The onset of symptoms was sudden in 8/14 cases, and the symptoms of myelitis were recurring in 3 cases. One case resulted in death. In most cases, treatment was based on corticosteroid pulse therapy (12/14), but some patients were treated with pulse cyclophosphamide (5/14), plasmapheresis (3/14), or rituximab (1/14). Generally, the therapeutic response was satisfactory, and complete improvement was seen in 9/14 patients. CONCLUSION: In light of the severe clinical presentation of TM and its morbidity and mortality, early diagnosis and aggressive treatment are vital for therapeutic success. We can verify the excellent therapeutic response, as we saw a complete improvement in 64% of patients. |
| | |
Authors:
|
Carlos Ewerton Maia Rodrigues; Jozélio Freire de Carvalho |
Related Documents
:
|
8004986 - A case of ideational apraxia with impairment of object use and preservation of object p... 17543556 - Renal vein thrombosis. 10506906 - Phenomenology of gasoline intoxication and withdrawal symptoms among adolescents in ind... 8600336 - Osteogenic sarcoma in the rothmund-thomson syndrome. 2711066 - Time series analysis of syphilis surveillance data. 2628336 - Bilateral intra-articular loose bodies of the elbow in an adolescent bmx rider. |
Publication Detail:
|
Type: Journal Article Date: 2010-08-10 |
Journal Detail:
|
Title: Seminars in arthritis and rheumatism Volume: 40 ISSN: 1532-866X ISO Abbreviation: Semin. Arthritis Rheum. Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-01-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 1306053 Medline TA: Semin Arthritis Rheum Country: United States |
Other Details:
|
Languages: eng Pagination: 349-57 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
|
Research Fellow, Rheumatology Division, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo and College of Medicine of Universidade de São Paulo, São Paulo, SP, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Validation of psoriatic arthritis diagnoses in electronic medical records using natural language pro...
Next Document: Growth-suppressing function of glypican-3 (GPC3) via insulin like growth factor II (IGF-II) signalin...