Document Detail


Clinical and Quality Evaluation of Red Blood Cell Units Collected Via Apheresis Versus Those Obtained Manually.
MedLine Citation:
PMID:  25051076     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
To evaluate the impact of collection procedure on the in vitro quality of red blood cells (RBC), we studied 30 units of apheresis-prepared RBC (ARBC) and 30 units of manually collected RBC (MRBC). We performed assays on day 1 and day 21 of the study, evaluating red cell mass volume (RCM); rate of hemolysis; pH, and levels of sodium, potassium, adenosine triphosphate (ATP), 2,3-diphosphoglycerate (2,3-DPG) and glucose. Eight patients with aplastic anemia received RBC transfusions of both components and their post-transfusion hematocrit (HCT) levels were compared. On day 21, we observed a significant drop of sodium and glucose levels in the ARBC group, compared with the MRBC group (P <.05). ARBC group demonstrated higher RCM that provided significantly higher HCT values to our group of anemic patients (P <.05). Hemolysis was significantly lower in the ARBC group, compared with the MRBC group (P <.05). At day 21, both groups had no detectable 2,3-DPG. Specimens from both groups retained ATP in sufficiently healthy amounts. The ARBC group demonstrated higher RCM and lower hemolysis levels compared with the MRBC group.
Authors:
Eiman Hussein; Azza Enein
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Laboratory medicine     Volume:  45     ISSN:  0007-5027     ISO Abbreviation:  Lab Med     Publication Date:  2014  
Date Detail:
Created Date:  2014-7-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0250641     Medline TA:  Lab Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  238-243     Citation Subset:  -    
Copyright Information:
Copyright© by the American Society for Clinical Pathology (ASCP).
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