| Clinical profiles of hypertrophic cardiomyopathy with apical phenotype--comparison of pure-apical form and distal-dominant form. | |
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MedLine Citation:
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PMID: 19838003 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Hypertrophic cardiomyopathy (HCM) with an apical phenotype, in which hypertrophy of the myocardium predominantly involves the apex of the left ventricle, is not uncommon in Japan, but its morphologic variations are not well recognized. The aim of this study was to investigate if these variations have different clinical characteristics although they are still confused to be the same. METHODS AND RESULTS: Patients with the apical phenotype were divided into 2 groups, the "pure-apical" form and the "distal-dominant" form, and their clinical profiles were compared. From the study cohort of 264 patients with HCM, 80 (30%) were classified as having the apical phenotype: 51 with the pure-apical form and 29 with the distal-dominant form. The age at diagnosis was approximately 60 years, and in both groups the majority were male. The distal-dominant group had a significantly larger left atrial diameter (43 vs 39 mm) and higher ratio of proven familial HCM (28 vs 6%), and were more symptomatic (New York Heart Association >or=3) at presentation (17 vs 0%). The event-free rate of cardiovascular events in patients with the distal-dominant form was significantly worse (log-rank P=0.012) than that in patients with the pure-apical form (follow-up period: asymptotically approximately 5 years). CONCLUSIONS: The 2 phenotypes of apical HCM should be recognized and distinguished clinically. |
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Authors:
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Toru Kubo; Hiroaki Kitaoka; Makoto Okawa; Takayoshi Hirota; Eri Hoshikawa; Kayo Hayato; Naohito Yamasaki; Yoshihisa Matsumura; Toshikazu Yabe; Masanori Nishinaga; Jun Takata; Yoshinori L Doi |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-10-17 |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 73 ISSN: 1347-4820 ISO Abbreviation: Circ. J. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-26 Completed Date: 2010-01-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
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Languages: eng Pagination: 2330-6 Citation Subset: IM |
Affiliation:
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Department of Medicine and Geriatrics, Kochi Medical School, Nankoku, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age of Onset Aged Aged, 80 and over Asian Continental Ancestry Group Cardiomyopathy, Hypertrophic* / complications, diagnosis, ethnology, mortality, physiopathology Cardiomyopathy, Hypertrophic, Familial* / complications, diagnosis, ethnology, mortality, physiopathology Child Disease Progression Disease-Free Survival Echocardiography Electrocardiography Female Humans Japan Male Middle Aged Phenotype Prognosis Retrospective Studies Severity of Illness Index Time Factors Young Adult |
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