| The clinical problem of hyperinsulinemic hypoglycemia and resultant infantile spasms. | |
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MedLine Citation:
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PMID: 20956428 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hyperinsulinemic hypoglycemia (HH) is a cause of severe hypoglycemia in the newborn and infancy period and is associated with a high risk of neurologic handicap and epilepsy. Infantile spasms after exposure to HH is rare and has been described in only 1 previous report. We report the clinical, biochemical, and neurodevelopmental characteristics of 5 patients with neonatal-onset HH who subsequently developed infantile spasms. All 5 patients had neonatal-onset HH of varying severity and duration. These patients presented with the characteristic ictal pattern of spasms in clusters at a mean age of 6.6 months. Characteristic hypsarrhythmia was noted in only 3 of 5 patients. Structural abnormality was found in only 1 of 4 patients who underwent MRI of the brain. Infantile spasms responded to medical treatment in 3 patients, spasms in 1 patient were refractory to antiepileptic drugs, and treatment duration was insufficient for us to comment on the response in 1 patient. Developmental delay was evident in all of them. In conclusion neonatal HH of varying severity is associated with later (after a latent period) development of infantile spasms. The latent period before the onset of the spasms can be variable; hence, long-term neurodevelopmental follow-up (until 1 year of age) is necessary. |
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Authors:
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Anitha Kumaran; Sri Kar; Ritika R Kapoor; Khalid Hussain |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2010-10-18 |
Journal Detail:
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Title: Pediatrics Volume: 126 ISSN: 1098-4275 ISO Abbreviation: Pediatrics Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-02 Completed Date: 2010-11-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: United States |
Other Details:
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Languages: eng Pagination: e1231-6 Citation Subset: AIM; IM |
Affiliation:
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Developmental Endocrinology Research Group, Clinical and Molecular Genetics Unit, Institute of Child Health, University College London, 30 Guilford St, London WC1N 1EH, United Kingdom. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anticonvulsants
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therapeutic use Brain / pathology Developmental Disabilities / diagnosis, etiology Diagnosis, Differential Electroencephalography / drug effects Female Follow-Up Studies Humans Infant Infant, Newborn Magnetic Resonance Imaging Male Persistent Hyperinsulinemia Hypoglycemia of Infancy / complications*, diagnosis Spasms, Infantile / diagnosis, drug therapy, etiology* |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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