| Clinical Prediction Score for Nasal CPAP Failure in Pre-term VLBW Neonates with Early Onset Respiratory Distress. | |
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MedLine Citation:
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PMID: 20558382 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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We prospectively observed 62 pre-term very low birth weight neonates initiated on nasal continuous positive airway pressure (CPAP) for respiratory distress in the first 24 h of life to devise a clinical score for predicting its failure. CPAP was administered using short binasal prongs with conventional ventilators. On multivariate analysis, we found three variables-gestation <28 weeks [adjusted odds ratio (OR) 6.5; 95% confidence interval (CI) 1.5-28.3], pre-term premature rupture of membranes [adjusted OR 5.3; CI 1.2-24.5], and product of CPAP pressure and fraction of inspired oxygen ≥1.28 at initiation to maintain saturation between 88% and 93% [adjusted OR 3.9; CI 1.0-15.5] to be independently predictive of failure. A prediction model was devised using weighted scores of these three variables and lack of exposure to antenatal steroids. The clinical scoring system thus developed had 75% sensitivity and 70% specificity for prediction of CPAP failure (area under curve: 0.83; 95% CI 0.71-0.94). |
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Authors:
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Mrinal S Pillai; Mari J Sankar; Kalaivani Mani; Ramesh Agarwal; Vinod K Paul; Ashok K Deorari |
Publication Detail:
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Type: Journal Article Date: 2010-06-16 |
Journal Detail:
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Title: Journal of tropical pediatrics Volume: 57 ISSN: 1465-3664 ISO Abbreviation: J. Trop. Pediatr. Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-07-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8010948 Medline TA: J Trop Pediatr Country: England |
Other Details:
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Languages: eng Pagination: 274-9 Citation Subset: IM |
Affiliation:
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Division of Neonatology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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