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Clinical Phenotype of Dementia after Traumatic Brain Injury.
MedLine Citation:
PMID:  23374007     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Traumatic brain injury (TBI) in early to mid-life is associated with an increased risk of dementia in late life. It is unclear whether TBI results in acceleration of Alzheimer's disease (AD) like pathology, or has features of another dementing condition, such as Chronic Traumatic Encephalopathy (CTE), which is associated with more prominent mood, behavior, and motor disturbances than AD. Data from the National Alzheimer's Coordinating Center (NACC) Uniform Data Set (UDS) was obtained over a 5 year period. Categorical data was analyzed using Fisher's exact test. Continuous parametric data was analyzed using Student's t-test. Non-parametric data was analyzed using the Mann-Whitney test. 877 individuals with dementia who had sustained TBI were identified in the NACC database. Only TBI with chronic deficit or dysfunction was associated with increased risk of dementia. Patients with dementia after TBI (n=62) were significantly more likely to experience depression, anxiety, irritability, and motor disorders than patients with probable AD. Autopsy data was available for 20 of the 62 TBI patients. Of the patients with TBI, 62% met National Institute of Aging (NIA)-Reagan "High Likelihood" criteria for AD. We conclude that TBI with chronic deficit or dysfunction is associated with an increased odds ratio for dementia. Clinically, patients with dementia associated with TBI were more likely to have symptoms of depression, agitation, irritability, and motor dysfunction than patients with probable AD. These findings suggest that dementia in individuals with a history of TBI may be distinct from AD.
Authors:
Nasreen Sayed; Carlee Culver; Kristen Dams-O'Connor; Flora Hammond; Ramon Diaz-Arrastia
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-4
Journal Detail:
Title:  Journal of neurotrauma     Volume:  -     ISSN:  1557-9042     ISO Abbreviation:  J. Neurotrauma     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8811626     Medline TA:  J Neurotrauma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
University of Texas Southwestern Medical Center, Neurology, Dallas, Texas, United States; Nasreen.Sayed@UTSouthwestern.edu.
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