| Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in northeastern Brazil. | |
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MedLine Citation:
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PMID: 20559542 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Outbreaks of orally transmitted Trypanosoma cruzi continue to be reported in Brazil and are associated with a high mortality rate, mainly due to myocarditis. METHODS: This study is a detailed report on the disease progression of acute Chagas disease in 13 patients who were infected during two micro-outbreaks in two northeastern Brazilian towns. Clinical outcomes as well as EKG and ECHO results are described, both before and after benznidazole treatment. RESULTS: Fever and dyspnea were the most frequent symptoms observed. Other clinical findings included myalgia, periorbital edema, headache and systolic murmur. Two patients died of cardiac failure before receiving benznidazole treatment. EKG and ECHO findings frequently showed a disturbance in ventricular repolarization and pericardial effusion. Ventricular dysfunction (ejection fraction <55%) was present in 27.3% of patients. After treatment, EKG readings normalized in 91.7% of patients. Ventricular repolarization abnormalities persisted in 50% of the patients, while sinus bradycardia was observed in 18%. The systolic ejection fraction normalized in two out of three patients with initially depressed ventricular function, while pericardial effusion disappeared. CONCLUSIONS: Myocarditis is frequently found and potentially severe in patients with acute Chagas disease. Benznidazole treatment may improve clinical symptoms, as well as EKG and ECHO findings. |
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Authors:
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Claudilson J C Bastos; Roque Aras; Gildo Mota; Francisco Reis; Juarez Pereira Dias; Robson Silva de Jesus; Miralba Silva Freire; Eline G de Araújo; Juliana Prazeres; Maria Fernanda Rios Grassi |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-15 |
Journal Detail:
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Title: PLoS neglected tropical diseases Volume: 4 ISSN: 1935-2735 ISO Abbreviation: PLoS Negl Trop Dis Publication Date: 2010 |
Date Detail:
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Created Date: 2010-06-18 Completed Date: 2010-09-24 Revised Date: 2010-09-30 |
Medline Journal Info:
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Nlm Unique ID: 101291488 Medline TA: PLoS Negl Trop Dis Country: United States |
Other Details:
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Languages: eng Pagination: e711 Citation Subset: IM |
Affiliation:
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Medicine and Human Health PhD Program, Bahian School of Medicine and Public Health, Bahia, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adolescent Adult Brazil / epidemiology Chagas Disease / diagnosis, drug therapy*, epidemiology, transmission Child Disease Outbreaks* Echocardiography, Doppler Electrocardiography Female Humans Male Nitroimidazoles / therapeutic use Radiography, Thoracic Treatment Outcome Trypanocidal Agents / therapeutic use Trypanosoma cruzi / isolation & purification |
| Chemical | |
Reg. No./Substance:
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0/Nitroimidazoles; 0/Trypanocidal Agents; 22994-85-0/benzonidazole |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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