| Clinical outcomes and predictors for ESRD and mortality in primary GN. | |
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MedLine Citation:
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PMID: 22798538 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVES: Relatively little is known about the long-term outcomes of different histologic types of primary glomerulonephritis in Asian populations. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: From 1993 to 2006, 987 patients undergoing renal biopsy were studied, and 580 patients (mean age=44.4 years, male=58.5%) with the four most common forms of glomerulonephritis (membranous nephropathy, focal and segmental glomerulosclerosis, IgA nephropathy, and minimal change disease) were selected for analysis. Median follow-up period was 5.9 (interquartile range=5.7) years. RESULTS: The focal and segmental glomerulosclerosis group displayed the highest incidence of ESRD (25.8%) and the fastest decline of estimated GFR (4.6 ml/min per 1.73 m(2) per year). The IgA nephropathy group also had a higher rate of ESRD than the membranous nephropathy patients (19.2% versus 4.3%, P<0.001). In contrast, the membranous nephropathy group exhibited an overall death rate similar to the focal and segmental glomerulosclerosis group (17.2% versus 14.4%) but higher than the IgA nephropathy and minimal change disease patients (4.6% and 3.7%, respectively, P<0.001). The most powerful predictor for ESRD was focal and segmental glomerulosclerosis, whereas the strongest predictor for all-cause mortality was membranous nephropathy with higher proteinuria. Protectors against ESRD included male sex and higher hemoglobin. CONCLUSIONS: Most predictors for ESRD and overall mortality found in this ethnic Chinese cohort were similar to other studies. However, some risk factors linked with distinct glomerular pathologies displayed differential clinical outcomes. |
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Authors:
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Yu-Hsiang Chou; Yu-Chung Lien; Fu-Chang Hu; Wei-Chou Lin; Chih-Chin Kao; Chun-Fu Lai; Wen-Chih Chiang; Shuei-Liong Lin; Tun-Jun Tsai; Kwan-Dun Wu; Yung-Ming Chen |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2012-07-12 |
Journal Detail:
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Title: Clinical journal of the American Society of Nephrology : CJASN Volume: 7 ISSN: 1555-905X ISO Abbreviation: Clin J Am Soc Nephrol Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-09-10 Completed Date: 2013-01-29 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 101271570 Medline TA: Clin J Am Soc Nephrol Country: United States |
Other Details:
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Languages: eng Pagination: 1401-8 Citation Subset: IM |
Affiliation:
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Renal Division, Department of Internal Medicine, National Taiwan University Hospital, Yun-Lin Branch, Yunlin County, Taiwan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Asian Continental Ancestry Group Biological Markers / blood Biopsy Chi-Square Distribution Disease Progression Female Glomerulonephritis / blood, ethnology, mortality*, pathology, therapy Glomerulonephritis, IGA / mortality, pathology Glomerulonephritis, Membranous / mortality, pathology Glomerulosclerosis, Focal Segmental / mortality, pathology Hemoglobins / metabolism Humans Incidence Kaplan-Meier Estimate Kidney / pathology Kidney Failure, Chronic / blood, ethnology, mortality*, pathology, therapy Male Middle Aged Multivariate Analysis Nephrosis, Lipoid / mortality, pathology Prognosis Proportional Hazards Models Proteinuria / mortality Renal Dialysis Retrospective Studies Risk Assessment Risk Factors Sex Factors Taiwan / epidemiology Time Factors Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Hemoglobins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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