| Clinical outcomes and patterns of failure after intensity-modulated radiotherapy for nasopharyngeal carcinoma. | |
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MedLine Citation:
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PMID: 20452132 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To study and report the clinical outcomes and patterns of failure after intensity-modulated radiotherapy (IMRT) for nasopharyngeal carcinoma (NPC). METHODS AND MATERIALS: The treatment outcomes of NPC patients treated with IMRT at Pamela Youde Nethersole Eastern Hospital between 2005 and 2007 were reviewed. The location and extent of locoregional failures were transferred to the pretreatment planning computed tomography for dosimetry analysis. Statistical analyses were performed on dose coverage and locoregional failures. RESULTS: A total of 193 NPC patients were analyzed; 93% had Stage III/IV disease. Median follow-up was 30 months. Overall disease failure (at any site) developed in 35 patients. Among these, there were 23 distant metastases, 16 local failures, and 9 regional failures. Four of the locoregional failures were marginal. Dose conformity with IMRT was excellent. Patients with at least 66.5 Gy to their target volumes had significantly less locoregional failure. The 2-year local progression-free, regional progression-free, distant metastasis-free, and overall survival rates were 95%, 96%, 90%, and 92%, respectively. CONCLUSIONS: Intensity-modulated radiotherapy provides excellent locoregional control for NPC. Distant metastasis remains the most difficult challenge, and more effective systemic agents should be explored for patients presenting with advanced locoregional diseases. |
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Authors:
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Wai Tong Ng; Michael C H Lee; Wai Man Hung; Cheuk Wai Choi; Kin Chung Lee; Oscar S H Chan; Anne W M Lee |
Publication Detail:
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Type: Journal Article Date: 2010-05-06 |
Journal Detail:
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Title: International journal of radiation oncology, biology, physics Volume: 79 ISSN: 1879-355X ISO Abbreviation: Int. J. Radiat. Oncol. Biol. Phys. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-03 Completed Date: 2011-02-01 Revised Date: 2011-12-06 |
Medline Journal Info:
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Nlm Unique ID: 7603616 Medline TA: Int J Radiat Oncol Biol Phys Country: United States |
Other Details:
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Languages: eng Pagination: 420-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Hong Kong. ngwt1@ha.org.hk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols / therapeutic use Chemotherapy, Adjuvant Cisplatin / administration & dosage Disease-Free Survival Female Fluorouracil / administration & dosage Follow-Up Studies Humans Magnetic Resonance Imaging Male Middle Aged Nasopharyngeal Neoplasms* / drug therapy, pathology, radiotherapy, secondary Organs at Risk / anatomy & histology Radiotherapy Dosage Radiotherapy, Intensity-Modulated* / adverse effects, methods Remission Induction Treatment Outcome Tumor Burden Young Adult |
| Chemical | |
Reg. No./Substance:
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15663-27-1/Cisplatin; 51-21-8/Fluorouracil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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