| Clinical outcome and prognosis of anti-neutrophil cytoplasmic antibody-associated vasculitis in Japan. | |
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MedLine Citation:
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PMID: 20173346 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: We conducted a broad survey of 99 patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis and investigated both prognosis and outcomes. METHODS: Clinical data evaluated were age, sex, patient survival, renal survival, serum albumin, serum creatinine, urinary protein, hematuria, C-reactive protein (CRP), ANCA titer, IgG and the Birmingham Vasculitis Activity Score (BVAS). RESULTS: The patient survival rate at 6 months after onset was 84.8%, and that at 2 years after onset was 82.0%. Most deaths were within 6 months of onset. Infection accounted for 9 deaths (60.0%). Infection together with pulmonary involvement of active vasculitis accounted for 2 deaths (13.3%). Organ-specific involvement of active vasculitis alone caused 3 deaths (20.0%). Others died of cardiac events. At 1 and 3 months after onset, BVAS (p < 0.0001, p = 0.002), albumin (p = 0.006, p = 0.0004) and CRP (p = 0.04, p = 0.0002) were also associated with patient death. CONCLUSION: To improve the prognosis of those with ANCA-associated vasculitis, the intensity of initial treatment should be aimed at disease severity. Employing BVAS improved the ability to evaluate therapeutic responses. Finally, prescription with sulfamethoxazole-trimethoprim during the induction therapy with immunosuppressive agents may be advised. |
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Authors:
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Mitsuyo Itabashi; Takashi Takei; Yasuko Yabuki; Hitoe Suzuki; Minoru Ando; Mayuko Akamatsu; Mayuko Yamazaki; Michihiro Mitobe; Yoshihiko Watanabe; Takahiro Mochizuki; Kosaku Nitta |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-02-19 |
Journal Detail:
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Title: Nephron. Clinical practice Volume: 115 ISSN: 1660-2110 ISO Abbreviation: Nephron Clin Pract Publication Date: 2010 |
Date Detail:
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Created Date: 2010-04-30 Completed Date: 2010-08-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101159763 Medline TA: Nephron Clin Pract Country: Switzerland |
Other Details:
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Languages: eng Pagination: c21-7 Citation Subset: IM |
Affiliation:
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Department of Medicine, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan. m-itaba@fb-4.so-net.ne.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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therapeutic use* Adult Aged Aged, 80 and over Anti-Inflammatory Agents / therapeutic use Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / mortality*, therapy* Female Humans Japan / epidemiology Male Middle Aged Outcome Assessment (Health Care) Prevalence Prognosis Risk Assessment / methods Risk Factors Survival Analysis Survival Rate Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Anti-Inflammatory Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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