| Clinical and Metabolic Features of Adult-Onset Diabetes Caused by ABCC8 Mutations. | |
| | |
MedLine Citation:
|
PMID: 22210575 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVEGain-of-function ABCC8/sulfonylurea (SU) receptor 1 mutations cause neonatal diabetes mellitus (NDM) or late-onset diabetes in adult relatives. Given the effectiveness of SU treatment in ABCC8-NDM patients, we further characterized late-onset ABCC8-associated diabetes.RESEARCH DESIGN AND METHODSSeven adult subjects from three NDM families and one family with type 2 diabetes were studied. Insulin secretion and insulin sensitivity were assessed using clamp techniques. We screened 139 type 2 diabetic patients who were well controlled by SU for ABCC8 mutations.RESULTSABCC8 mutation carriers exhibited glucose intolerance, frank diabetes, or insulin-requiring diabetes since diagnosis. HbA(1c) improved in five SU-treated patients. Insulin secretion capacity was impaired in three patients compared with adult control subjects but was restored after a 4-week SU trial in two patients. Cohort screening revealed four SU-treated patients with ABCC8 mutations, two of which are likely causal.CONCLUSIONSAlthough of rare occurrence, recognition of adult-onset ABCC8-associated diabetes may help in targeting patients for SU therapy. |
| | |
Authors:
|
Jean-Pierre Riveline; Elise Rousseau; Yves Reznik; Sabrina Fetita; Julien Philippe; Aurélie Dechaume; Agnès Hartemann; Michel Polak; Catherine Petit; Guillaume Charpentier; Jean-François Gautier; Philippe Froguel; Martine Vaxillaire |
Related Documents
:
|
8503435 - Calcium antagonists and the diabetic hypertensive patient. 16160725 - Diabetic nephropathy: a review of the past, present and future perspectives - part i. 18090675 - Insight into the genetics of diabetic nephropathy through the study of mice. 8542735 - Diabetic renal disease: the quest for normotension--and beyond. 9437215 - The severity of coronary atherosclerosis in type 2 diabetes mellitus is related to the ... 11495195 - A model for internal derangement and osteoarthritis of the temporomandibular joint with... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-30 |
Journal Detail:
|
Title: Diabetes care Volume: - ISSN: 1935-5548 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2012-1-2 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7805975 Medline TA: Diabetes Care Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Diabetes and Endocrinology, Centre Hospitalier Sud Francilien, Corbeil-Essonnes, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pioglitazone and Bladder Cancer: A population-based study of Taiwanese.
Next Document: Benefits and Safety of Long-Term Fenofibrate Therapy in People With Type 2 Diabetes and Renal Impair...