| Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers. | |
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MedLine Citation:
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PMID: 20970030 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The most significant long-term complication of radiotherapy in the head-and-neck region is hyposalivation and its related complaints, particularily xerostomia. This review addresses the pathophysiology underlying irradiation damage to salivary gland tissue, the consequences of radiation injury, and issues contributing to the clinical management of salivary gland hypofunction and xerostomia. These include ways to (1) prevent or minimize radiation injury of salivary gland tissue, (2) manage radiation-induced hyposalivation and xerostomia, and (3) restore the function of salivary gland tissue damaged by radiotherapy. |
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Authors:
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Arjan Vissink; James B Mitchell; Bruce J Baum; Kirsten H Limesand; Siri Beier Jensen; Philip C Fox; Linda S Elting; Johannes A Langendijk; Robert P Coppes; Mary E Reyland |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: International journal of radiation oncology, biology, physics Volume: 78 ISSN: 1879-355X ISO Abbreviation: Int. J. Radiat. Oncol. Biol. Phys. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-25 Completed Date: 2010-11-10 Revised Date: 2011-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7603616 Medline TA: Int J Radiat Oncol Biol Phys Country: United States |
Other Details:
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Languages: eng Pagination: 983-91 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Grongingen, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Gene Therapy
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methods Head and Neck Neoplasms / radiotherapy* Humans Radiation Injuries / prevention & control* Radiation-Protective Agents / therapeutic use Radiotherapy / methods, trends Saliva, Artificial / therapeutic use Salivary Glands / radiation effects* Stem Cell Transplantation / methods Xerostomia / etiology, prevention & control, therapy* |
| Grant Support | |
ID/Acronym/Agency:
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R01 DE015648-08/DE/NIDCR NIH HHS; R13 DE19330/DE/NIDCR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Radiation-Protective Agents; 0/Saliva, Artificial |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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