Document Detail

Clinical, MRI, CSF and electrophysiological findings in different stages of multiple sclerosis.
MedLine Citation:
PMID:  16378679     Owner:  NLM     Status:  MEDLINE    
Effective therapy in the earliest stages of multiple sclerosis (MS) demands early correct diagnosis. Retrospective analysis included 130 patients (90 women) with a median age of 35.5 years, median duration of the disease of 2 years and median EDSS score of 3.0. Twenty-seven patients had clinically isolated syndrome (CIS) suggestive of MS, 66 relapsing-remitting (RR) MS, 19 secondary progressive (SP) MS and 18 primary progressive (PP) MS. The predominant symptoms were sensory in 52% of the patients with CIS compared to 27% in patients with RRMS, whereas they were more often motor in patients with PPMS. Patients with CIS had higher CSF cell counts than patients diagnosed in later stages of the disease and oligoclonal bands were found in 89% of all patients without statistically significant differences between the subgroups. Prolonged latencies of visual evoked potentials (VEP) were found in only 29% of patients with CIS compared to 66% in RRMS, 75% in SPMS and 65% of PPMS patients. Fifty-six percent of patients with CIS, 88% with RRMS, 74% with SPMS and 78% of patients with PPMS fulfilled modified the Barkhof et al. MRI criteria at the time of diagnosis. Patients in early MS often present with sensory symptoms. Brain MRI can be inconclusive in over 40% of patients with CIS but the elevated CSF cell count and positive oligoclonal bands are helpful in establishing the diagnosis of CIS suggestive of MS. In later stages of the disease the combination of clinical features, MRI, prolonged VEP latencies and positive CSF oligoclonal bands secures the correct diagnosis.
Uros Rot; Anton Mesec
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Publication Detail:
Type:  Journal Article     Date:  2005-12-27
Journal Detail:
Title:  Clinical neurology and neurosurgery     Volume:  108     ISSN:  0303-8467     ISO Abbreviation:  Clin Neurol Neurosurg     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-06     Completed Date:  2006-05-25     Revised Date:  2009-10-14    
Medline Journal Info:
Nlm Unique ID:  7502039     Medline TA:  Clin Neurol Neurosurg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  271-4     Citation Subset:  IM    
Department of Neurology, Medical Centre, Zaloska 7, 1525 Ljubljana, Slovenia.
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MeSH Terms
Brain / pathology*
Cerebrospinal Fluid Proteins / cerebrospinal fluid*
Evoked Potentials / physiology*
Immunoglobulin G / cerebrospinal fluid*
Leukocyte Count
Middle Aged
Multiple Sclerosis* / metabolism,  pathology,  physiopathology
Spinal Cord / pathology*
Reg. No./Substance:
0/Cerebrospinal Fluid Proteins; 0/Immunoglobulin G

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