Document Detail


Clinical, Laboratory, and Therapeutic Analyses of 21 Patients with Neonatal Thrombosis and Antiphospholipid Antibodies: A Literature Review.
MedLine Citation:
PMID:  25133197     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objectives. A review of the literature reports neonatal thrombosis and antiphospholipid antibodies cases through a retrospective study that focuses on the pathogenesis and main clinical and laboratory manifestations of this disease. Methods. The case reports were selected from PubMed. The keywords used to search were neonatal, antiphospholipid syndrome, thrombosis, and antiphospholipid antibodies. References that were published from 1987 to 2013 were reviewed. Results. Twenty-one cases of neonatal thrombosis and antiphospholipid antibodies were identified. Ten children were born preterm (before 37 weeks). Arterial involvement (17/21) was predominant, of which stroke (12/17) was the most prevalent clinical manifestation. Anti-cardiolipin antibodies were predominant (13/21) in the antiphospholipid antibody profiles. Treatments were based on the use of symptomatics such as antiepileptics (8/21), and 6/21 patients received heparin. There were 4 deaths (4/21); otherwise, the children recovered well, especially the neonates who suffered from strokes (9/12). Conclusion. Neonatal thrombosis and antiphospholipid antibodies are rare. The development of thrombotic manifestations in neonates seems not to be associated exclusively with the aPL, but their etiology may be linked to pre- and perinatal events. We noted good therapeutic responses, especially in stroke patients, who presented with favorable outcomes in 82% of the cases.
Authors:
Marcus Vinicius da Costa Peixoto; Jozélio Freire de Carvalho; Carlos Ewerton Maia Rodrigues
Related Documents :
16649457 - Trauma related to sexual assault in calabar, south eastern nigeria.
17587067 - An unusual presentation of whiplash injury: long thoracic and spinal accessory nerve in...
7473987 - Delayed embolization of a shotgun pellet from the chest to the middle cerebral artery.
7256457 - Avulsion of the insertion of the pectoralis major muscle. a case report.
22737307 - Spontaneous concomitant intracranial and spinal subdural hematomas in association with ...
11213847 - A trans-cultural comparison of four psychiatric case-finding instruments in a welsh com...
Publication Detail:
Type:  REVIEW     Date:  2014-7-17
Journal Detail:
Title:  Journal of immunology research     Volume:  2014     ISSN:  2314-7156     ISO Abbreviation:  J Immunol Res     Publication Date:  2014  
Date Detail:
Created Date:  2014-8-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101627166     Medline TA:  J Immunol Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  672603     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  T CD3(+)CD8(+) Lymphocytes Are More Susceptible for Apoptosis in the First Trimester of Normal Human...
Next Document:  Uncomplicated Diverticular Disease: Innate and Adaptive Immunity in Human Gut Mucosa before and afte...