Document Detail


Clinical, Laboratory, Endoscopical and Histological Characteristics Predict Severe Ulcerative Colitis.
MedLine Citation:
PMID:  23353708     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background/Aims: Ulcerative colitis is a remitting and relapsing chronic inflammatory disorder of the colon with a mortality rate of 7% from acute severe UC. Methodology: A retrospective study of the correlation of clinical indicators, laboratory indicators, endoscopical features, and histological features with clinical severity of UC was conducted in 125 UC cases. Results: Diarrhea, mucous and pus in the stool, fever, anemia, weight loss and tachycardia symptoms and the erythrocyte sedimentation rate, concentrations of C-reactive protein, amount of white blood cells and platelets, and positive occult blood test positively correlated with the severity of disease. Whereas, serum total protein, albumin, and hemoglobin levels negatively correlated with the severity of UC. The endoscopic observations of mucosa bleeding, granular mucosa, pseudopolyps, pouch lighter or disappeared, and luminal stenosis as well as the grade and extent of disease were significantly associated with the severity of UC. Histological grade and granular mucosa were significantly associated with the severity of UC. Failure of conservative treatment, severely low gastrointestinal bleeding, and the discovery of a suspicious cancer in the biopsy are the main indicators for colectomy. Conclusions: Significant reduction in serum total protein, albumin, and hemoglobin concentration is a relatively specific indicator of severe UC.
Authors:
Chunlian Wang; Linfang He; Jie Zhang; Chunhui Ouyang; Xiaoping Wu; Fanggen Lu; Xiaowei Liu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-28
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  60     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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