| Clinical Improvement after Extracranial Venoplasty in Multiple Sclerosis. | |
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MedLine Citation:
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PMID: 22951366 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: This study proposed to prospectively evaluate safety and clinical changes in outpatient endovascular treatment in patients with multiple sclerosis (MS) and chronic cerebrospinal venous insufficiency (CCSVI). MATERIALS AND METHODS: Two hundred fifty-nine patients with MS were followed with the Multiple Sclerosis Impact Scale (MSIS-29) before and for 1and 6 months after treatment of extracranial internal jugular vein and azygos vein stenoses and occlusions using venous angioplasty, as well as stent placement in 2.5% of patients. Before treatment, the patients were tested with magnetic resonance (MR) venography and flow quantification. RESULTS: We found statistically significant improvements in the MSIS-29 scores (P < .01) at both 1 and 6 months. At 1 and 6 months, 67.9% and 53.6% were improved on the physical scale, respectively, and 53.0% and 44.4% were improved on the psychological scale, respectively. Women showed greater improvement than did men on the physical scale at 6 months (P = .01). Patients with primary progressive MS (PPMS) showed less improvement than did those with relapsing-remitting MS (RRMS) on the psychological scale at 1 month, and venoplasty treatment of more vein sites versus fewer vein sites showed greater improvement on the physical scale at both 1 and 6 months. Fifteen patients (6.3%) reported recurrent symptoms after clinical improvement and were treated again. There was one serious adverse event, a deep venous thrombosis at the catheter insertion site, which resolved with treatment. CONCLUSIONS: Endovascular treatment of CCSVI in patients with MS appears to be a safe procedure resulting in significant clinical improvement. |
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Authors:
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David Hubbard; Donald Ponec; Justin Gooding; Richard Saxon; Heidi Sauder; Mark Haacke |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-27 |
Journal Detail:
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Title: Journal of vascular and interventional radiology : JVIR Volume: - ISSN: 1535-7732 ISO Abbreviation: J Vasc Interv Radiol Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-9-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9203369 Medline TA: J Vasc Interv Radiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 SIR. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Applied fMRI Institute, Hubbard Foundation, San Diego, California. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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