Document Detail


Clinical implications of first-trimester screening.
MedLine Citation:
PMID:  20638575     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
First-trimester aneuploidy screening is associated with very high detection rates for Down syndrome and other chromosomal abnormalities. The clinical implications of early screening relate to prenatal diagnosis of chromosomal abnormalities and important information obtained at screening. Early screening can change the rate of invasive prenatal diagnosis and the gestational age of prenatal diagnosis and abortion, and lead to earlier prenatal diagnosis of certain major structural abnormalities. The detection of biochemical abnormalities associated with obstetric complications, such as low pregnancy-associated plasma protein A, could also affect the management and outcomes of some pregnancies.
Authors:
Stephen T Chasen
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-06-15
Journal Detail:
Title:  Clinics in laboratory medicine     Volume:  30     ISSN:  1557-9832     ISO Abbreviation:  Clin. Lab. Med.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-07-19     Completed Date:  2010-11-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8100174     Medline TA:  Clin Lab Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  605-11     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Affiliation:
Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10065, USA. stchasen@med.cornell.edu
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MeSH Terms
Descriptor/Qualifier:
Aneuploidy
Female
Humans
Predictive Value of Tests
Pregnancy
Pregnancy Trimester, First*
Prenatal Diagnosis*
Risk Assessment

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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