| Clinical implications of first-trimester screening. | |
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MedLine Citation:
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PMID: 20638575 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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First-trimester aneuploidy screening is associated with very high detection rates for Down syndrome and other chromosomal abnormalities. The clinical implications of early screening relate to prenatal diagnosis of chromosomal abnormalities and important information obtained at screening. Early screening can change the rate of invasive prenatal diagnosis and the gestational age of prenatal diagnosis and abortion, and lead to earlier prenatal diagnosis of certain major structural abnormalities. The detection of biochemical abnormalities associated with obstetric complications, such as low pregnancy-associated plasma protein A, could also affect the management and outcomes of some pregnancies. |
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Authors:
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Stephen T Chasen |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-06-15 |
Journal Detail:
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Title: Clinics in laboratory medicine Volume: 30 ISSN: 1557-9832 ISO Abbreviation: Clin. Lab. Med. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-07-19 Completed Date: 2010-11-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8100174 Medline TA: Clin Lab Med Country: United States |
Other Details:
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Languages: eng Pagination: 605-11 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10065, USA. stchasen@med.cornell.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aneuploidy Female Humans Predictive Value of Tests Pregnancy Pregnancy Trimester, First* Prenatal Diagnosis* Risk Assessment |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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