Document Detail


Clinical Impact of Genetically Determined Platelet Reactivity.
MedLine Citation:
PMID:  23149816     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Dual antiplatelet therapy with aspirin and clopidogrel dramatically reduced the rate of major adverse cardiac events following percutaneous coronary intervention. Clopidogrel is a prodrug which requires a two-step hepatic biotransformation thanks to the cytochrome P450 (CYP450) enzyme system. Genetic polymorphism of CYP450 system (e.g., CYP2C19*2) responsible for altered clopidogrel metabolism is a major cause of high on-treatment platelet reactivity (HTPR), which translates into thrombotic events in stented patients. Studies demonstrated that HTPR could be overcome in poor metabolizers thanks to increased loading doses or maintenance doses of clopidogrel or with the use of more potent antiplatelet agents such as prasugrel. Other genetic polymorphisms have also been correlated with HTPR: ABCB1, ATP2B2, and TIAM2. Large-scale randomized trials with clinical endpoints remain necessary to determine the optimal antiplatelet therapy in patients carrying genetic polymorphism associated with HTPR and thrombotic events.
Authors:
Marc Laine; Sébastien Arméro; Michaël Peyrol; Pascal Sbragia; Franck Thuny; Franck Paganelli; Laurent Bonello
Related Documents :
25149956 - Fraternal twins with autism, severe cognitive deficit, and epilepsy: diagnostic role of...
16531626 - Acetylation genotype and phenotype in patients with systemic lupus erythematosus.
23717576 - Rat model for dominant dystrophic epidermolysis bullosa: glycine substitution reduces c...
23930676 - Genetic variation in the ppara gene is associated with simvastatin-mediated cholesterol...
24955146 - Expanding the genetic basis of copy number variation in familial breast cancer.
25401736 - Cell fate decisions in malignant hematopoiesis: leukemia phenotype is determined by dis...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-13
Journal Detail:
Title:  Journal of cardiovascular translational research     Volume:  -     ISSN:  1937-5395     ISO Abbreviation:  J Cardiovasc Transl Res     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101468585     Medline TA:  J Cardiovasc Transl Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Département de Cardiologie, Centre Hospitalo-Universitaire Nord, Chemin des Bourrely, Marseille, France, lainemarc@hotmail.fr.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Stromal Cell-Derived Factor-1? as a Novel Biomarker for Hyperlipidemia.
Next Document:  Evaluation of arene ruthenium(ii) N-heterocyclic carbene complexes as organometallics interacting wi...