Document Detail


Clinical Heterogeneity of Desmoplastic Infantile Ganglioglioma: A Case Series and Literature Review.
MedLine Citation:
PMID:  22735886     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Desmoplastic infantile gangliogliomas (DIG) are intracranial tumors described in 1987 as benign lesions of infancy. A literature review and the clinical course of 3 patients reported herein suggest that the initial description should be amended. Nearly 23% of DIG cases occur in children older than 24 months. Approximately 40% of DIG cases require additional medical, radiation, and/or further surgical intervention, and 15% of infants and children develop leptomeningeal spread or die from DIG. Such adverse outcomes, combined with the recognition that DIG represents a heterogeneous disease, underscore the need for an expanded biological and molecular investigation.
Authors:
Trent R Hummel; Lili Miles; Francesco T Mangano; Blaise V Jones; James I Geller
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-25
Journal Detail:
Title:  Journal of pediatric hematology/oncology     Volume:  -     ISSN:  1536-3678     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9505928     Medline TA:  J Pediatr Hematol Oncol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
*Cancer and Blood Diseases Institute, Division of Oncology †Division of Pathology and Laboratory Medicine ‡Department of Pediatric Neurological Surgery §Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati OH.
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