| Clinical Features and Types of Von Willebrand Disease in Karachi. | |
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MedLine Citation:
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PMID: 21159712 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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This study was conducted on patients with a history of congenital bleeding disorders or with suspected bleeding tendencies. Laboratory analysis revealed Von Willebrand disease (VWD) in 68 (21.3%) of 318 participants with male to female ratio of 0.8: 1 (31 to 37) and median age 17 years (range 2-45 years). Type 3 being the most frequent, 35 (51.4%) of 68, type 2, 20 (29.4%) of 68, and lastly type 1, 13 (19.1%) of 68. A total of 55.8% patients with VWD presented with mucocutaneous bleeding. Menorrhagia was the most common presentation of female patients. Von Willebrand disease (21.3%) was the second common bleeding disorder and the most common coagulation defect among females with menorrhagia. However, the frequency in the study was quite low when compared to the western world. Similarly, low frequency of VWD type 1 might be due to the fact that only symptomatic patients visited us. Further studies are needed as there is limited information on VWD in the developing countries. This will help in the development of expertise for the accurate diagnosis & proper management. |
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Authors:
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Munira Borhany; Tahir Shamsi; Arshi Naz; Tasneem Farzana; Saqib Ansari; Muhammad Nadeem; Zia Ur Rehman; Zainab Sangii |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-12-15 |
Journal Detail:
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Title: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis Volume: - ISSN: 1938-2723 ISO Abbreviation: - Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508125 Medline TA: Clin Appl Thromb Hemost Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Thrombosis & Haemostasis Department of National Institute of Blood Disease & Bone Marrow Transplantation, Karachi, Pakistan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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