Document Detail


Clinical Features and Prognosis of Type 2 Myocardial Infarction in Vasospastic Angina.
MedLine Citation:
PMID:  25433303     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Although prognosis of vasospastic angina is generally considered excellent, vasospasm has been shown to be a cause of type 2 myocardial infarction. This study was performed to investigate the clinical characteristics and prognosis of patients with vasospastic angina complicated with type 2 myocardial infarction .
METHODS: We performed a retrospective analysis of 171 consecutive patients with definite vasospastic angina (median age, 64 years; 55.0% male) who visited our hospital with chest pain and in whom cardiac troponin I (TnI) level was measured between 2005 and 2013. The patients were divided into type 2 myocardial infarction and non-type 2 myocardial infarction groups. A diagnosis of type 2 myocardial infarction was based on serum TnI value > 99th percentile upper reference limit. The primary endpoint was a combination of non-fatal myocardial infarction or death by any cause.
RESULTS: Forty-two (24.6%) patients were diagnosed as type 2 myocardial infarction , and the type 2 myocardial infarction group had a higher incidence of combined endpoint compared with the non-type 2 myocardial infarction group during the median follow-up of 4.4 years (26.2% vs. 9.3%, respectively, P = 0.008). Type 2 myocardial infarction remained an independent predictor of combined endpoint even after adjusting by the Japanese Coronary Spasm Association risk factors for combined endpoint (HR: 2.84; 95% CI: 1.22 - 6.61; P = 0.02).
CONCLUSION: Approximately one quarter of vasospastic angina patients were associated with type 2 myocardial infarction, and this population should be identified as a new high-risk subgroup of vasospastic angina patients requiring an alternative treatment strategy.
Authors:
Yuya Matsue; Kazuki Yoshida; Masahiro Hoshino; Taishi Yonetsu; Makoto Suzuki; Akihiko Matsumura; Yuji Hashimoto; Masayuki Yoshida
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-26
Journal Detail:
Title:  The American journal of medicine     Volume:  -     ISSN:  1555-7162     ISO Abbreviation:  Am. J. Med.     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-29     Completed Date:  -     Revised Date:  2014-11-30    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Inc. All rights reserved.
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