| Clinical Features and Immunological Markers of Atopic Dermatitis in Elderly Patients. | |
| | |
MedLine Citation:
|
PMID: 22122980 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background: Atopic dermatitis (AD) is increasing among the elderly. Staphylococcus aureus colonization is one of the most important aggravating factors in AD. Objective: This study analyses the clinical features of AD in elderly patients and determines the pathogenic roles of staphylococcal superantigens in AD with low and high total IgE levels. Methods:S. aureus enterotoxin genes were evaluated using PCR. Additionally, S. aureus-specific IgE levels and peripheral blood lymphocyte profiles were assessed. Results: A total of 44 women and 77 men diagnosed with AD with a mean age of 68.92 ± 6.51 years were evaluated. In 17 (68%) patients with AD and low levels of total IgE, there was a positive correlation between the positive results for enterotoxin B, S. aureus-specific IgE antibodies and Th1 cytokine profiles (Spearman's rank correlation test, r = 0.89, p < 0.05). Conclusion: Our results indicate that AD patients with low total IgE levels differ in immunopathogenesis from AD patients with high circulating levels of total IgE AD. |
| | |
Authors:
|
Andrzej Bozek; Andreas Fisher; Barbara Filipowska; Bogdan Mazur; Jerzy Jarzab |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-24 |
Journal Detail:
|
Title: International archives of allergy and immunology Volume: 157 ISSN: 1423-0097 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-29 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9211652 Medline TA: Int Arch Allergy Immunol Country: - |
Other Details:
|
Languages: ENG Pagination: 372-378 Citation Subset: - |
Copyright Information:
|
Copyright © 2011 S. Karger AG, Basel. |
Affiliation:
|
Clinical Department of Internal Medicine, Dermatology and Allergology, Medical University of Silesia, Zabrze, Poland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The CETP I405V polymorphism is associated with an increased risk of Alzheimer's disease.
Next Document: The association of DNA damage response and nucleotide level modulation with the antibacterial mechan...