| Clinical Features and Efficacy of Antimalarial Treatment for Reticular Erythematous Mucinosis: A Case Series of 11 Patients. | |
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MedLine Citation:
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PMID: 21339419 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Reticular erythematous mucinosis (REM syndrome) is a rare cutaneous disease that predominantly affects the chest and upper back area of middle-aged women. Although antimalarial treatment is generally considered the most effective approach, only a few case reports exist on its use in REM syndrome. OBSERVATIONS: A total of 11 patients with REM syndrome (10 women and 1 man), mean age, 44 years (age range, 37-54 years), were included in this retrospective analysis. Ten of the 11 patients were cigarette smokers (91%), and 6 had concomitant autoimmune diseases (55%). Since no clinical score exists for REM syndrome, we used the validated Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) to evaluate the efficacy of antimalarial treatment. Overall, a significant decrease in the clinical score was observed from a median of 4 (range, 2-8) before initiation of treatment to 0 (range, 0-4) after 3 months of antimalarial therapy and to 0 (range, 0-4) after 12 months of therapy (P < .001). Two patients withdrew from the study owing to adverse gastrointestinal tract effects (nausea and vomiting); 2 relapsed after finishing their antimalarial regimens; 3 patients were free of disease 2 years after the end of treatment; and 4 patients were lost to follow-up. Conclusion Antimalarial agents significantly improve or completely clear the skin lesions of patients with REM syndrome and should be considered as a first-line therapy for this rare disease. |
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Authors:
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Alexander Kreuter; Nina Scola; Christian Tigges; Peter Altmeyer; Thilo Gambichler |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-21 |
Journal Detail:
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Title: Archives of dermatology Volume: - ISSN: 1538-3652 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372433 Medline TA: Arch Dermatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Dermatology, Venereology, and Allergology, Ruhr-University Bochum, Bochum, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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