| Clinical experience with a novel intracoronary perfusion catheter to treat no-reflow phenomenon in acute coronary syndromes. | |
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MedLine Citation:
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PMID: 20337859 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The no-reflow phenomenon is an often seen complication in patients presenting with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). This event is associated with poor prognosis and poses a therapeutic challenge. METHODS: This retrospective study cohort was composed of 30 patients who presented with ACS between September 2007 and April 2009, and developed no-reflow during subsequent PCI. The primary end-point was defined as normal Thrombolysis In Myocardial Infarction (TIMI) 3 flow with myocardial blush grade (MBG) >or=2 or an increase in TIMI flow by >or=2 grades with a MBG >or=2 after intracoronary drug infusion via the ClearWay (CW) RX perfusion catheter. RESULTS: The population presented with a relatively high prevalence of cardiovascular risk factors. ST-elevation myocardial infarction was the most common presentation (60.0%), while 20% of the patients presented with cardiogenic shock. After intracoronary infusion of nicardipine or nitroprusside using the CW catheter, TIMI flow improved from the baseline in 19 cases (63.3%, P < 0.001), and 16 patients (53.3%, P < 0.001) achieved normal coronary flow at the end of the procedure. The rate of in-hospital death was 6.7% (2 cases). No clinical differences were noted between those patients who successfully achieved normal coronary flow and those with persistent no-reflow. CONCLUSION: The infusion of intracoronary drugs using the novel perfusion CW RX catheter seems to be safe and could help to improve myocardial perfusion in a selected group of patients presenting with ACS who developed no-reflow during PCI. |
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Authors:
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Gabriel Maluenda; Itsik Ben-Dor; Cedric Delhaye; Manuel A Gonzalez; Sara D Collins; Rebecca Torguson; Zhenyi Xue; William O Suddath; Lowell F Satler; Kenneth M Kent; Joseph Lindsay; Augusto D Pichard; Ron Waksman |
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Publication Detail:
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Type: Journal Article Date: 2010-03-12 |
Journal Detail:
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Title: Journal of interventional cardiology Volume: 23 ISSN: 1540-8183 ISO Abbreviation: J Interv Cardiol Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-05-14 Completed Date: 2010-08-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8907826 Medline TA: J Interv Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 109-13 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Division of Cardiology, Washington Hospital Center, Washington, DC 20010, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Coronary Syndrome
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mortality,
physiopathology*,
therapy* Aged Angioplasty, Transluminal, Percutaneous Coronary / adverse effects* Catheterization* Cohort Studies Coronary Circulation* / drug effects Female Hospital Mortality Humans Male Middle Aged Nicardipine / administration & dosage Nitroprusside / administration & dosage Perfusion / instrumentation* Retrospective Studies Vasodilator Agents / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 15078-28-1/Nitroprusside; 55985-32-5/Nicardipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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