| Clinical evaluation of stereotactic target localization using 3-Tesla MRI for radiosurgery planning. | |
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MedLine Citation:
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PMID: 19515512 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Increasing the magnetic resonance imaging (MRI) field strength can improve image resolution and quality, but concerns remain regarding the influence on geometric fidelity. The objectives of the present study were to spatially investigate the effect of 3-Tesla (3T) MRI on clinical target localization for stereotactic radiosurgery. METHODS AND MATERIALS: A total of 39 patients were enrolled in a research ethics board-approved prospective clinical trial. Imaging (1.5T and 3T MRI and computed tomography) was performed after stereotactic frame placement. Stereotactic target localization at 1.5T vs. 3T was retrospectively analyzed in a representative cohort of patients with tumor (n = 4) and functional (n = 5) radiosurgical targets. The spatial congruency of the tumor gross target volumes was determined by the mean discrepancy between the average gross target volume surfaces at 1.5T and 3T. Reproducibility was assessed by the displacement from an averaged surface and volume congruency. Spatial congruency and the reproducibility of functional radiosurgical targets was determined by comparing the mean and standard deviation of the isocenter coordinates. RESULTS: Overall, the mean absolute discrepancy across all patients was 0.67 mm (95% confidence interval, 0.51-0.83), significantly <1 mm (p < .010). No differences were found in the overall interuser target volume congruence (mean, 84% for 1.5T vs. 84% for 3T, p > .4), and the gross target volume surface mean displacements were similar within and between users. The overall average isocenter coordinate discrepancy for the functional targets at 1.5T and 3T was 0.33 mm (95% confidence interval, 0.20-0.48), with no patient-specific differences between the mean values (p >.2) or standard deviations (p >.1). CONCLUSION: Our results have provided clinically relevant evidence supporting the spatial validity of 3T MRI for use in stereotactic radiosurgery under the imaging conditions used. |
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Authors:
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Derek MacFadden; BeiBei Zhang; Kristy K Brock; Mojgan Hodaie; Normand Laperriere; Michael Schwartz; May Tsao; Jeffrey Stainsby; Gina Lockwood; David Mikulis; Cynthia M?nard |
Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-06-08 |
Journal Detail:
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Title: International journal of radiation oncology, biology, physics Volume: 76 ISSN: 1879-355X ISO Abbreviation: Int. J. Radiat. Oncol. Biol. Phys. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-26 Completed Date: 2010-04-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7603616 Medline TA: Int J Radiat Oncol Biol Phys Country: United States |
Other Details:
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Languages: eng Pagination: 1472-9 Citation Subset: IM |
Affiliation:
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University of Toronto Faculty of Medicine, Toronto, ON, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Brain Neoplasms
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pathology*,
radiotherapy* Humans Magnetic Resonance Imaging / methods*, standards Prospective Studies Radiosurgery* Radiotherapy Planning, Computer-Assisted / methods* Reproducibility of Results Tumor Burden* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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