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Clinical Evaluation Of A Dioic Acid-Based Formulation On Facial Skin In An Indian Population.
MedLine Citation:
PMID:  22994950     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The aim of this work was to investigate the effects of 1,18-octadecen-9-dioic acid (dioic acid) and a Rumex occidentalis extract complex for their skin lightening action in an Indian population. Prior to the clinical study, the efficacy of dioic as an inhibitor of melanogenesis was confirmed on dark pigmented human melanocytes. As part of 12-week vehicle-controlled clinical study, the skin lightening effect of a test product containing 1% dioic acid, 2% of a Rumex occidentalis extract and sunscreens (SPF 15) was assessed on the facial skin of 71 Indian female volunteers. Change in skin colour was monitored by: (A) Chroma Meter(®) measurement (L*, a*, b*) and Individual Typology Angle (ITA˚) calculation and (B) Visual grading of standardised photographs by a dermatologist. Colorimetric measurements on volunteers' cheeks showed a significant increase of L* and ITA˚ compared to baseline after 4, 8 and 12 weeks of test product application. For both L* and ITA˚ measurements, changes were significantly different than the SPF 15-containing vehicle at weeks 4 and 12. These results were confirmed by the dermatological visual grading. The overall skin lightening action of the test product was beyond the one observed with the SPF 15 vehicle. These findings show that a dioic acid and Rumex occidentalis complex delivers a significant skin lightening effect on facial skin in an Indian population. © 2012 Society of Cosmetic Scientists and the Société Française de Cosmétologie.
Authors:
Eve Merinville; Adam J Byrne; Lene Visdal-Johnsen; Geraldine Bouvry; Johanna M Gillbro; Anthony V Rawlings; Aurelie Laloeuf
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-19
Journal Detail:
Title:  International journal of cosmetic science     Volume:  -     ISSN:  1468-2494     ISO Abbreviation:  Int J Cosmet Sci     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8007161     Medline TA:  Int J Cosmet Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Society of Cosmetic Scientists and the Société Française de Cosmétologie.
Affiliation:
Oriflame Skin Research Institute AB, Stockholm, Sweden.
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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