| Clinical and Electroencephalographic Effects of Folinic Acid Treatment in Rett Syndrome Patients. | |
| | |
MedLine Citation:
|
PMID: 21427443 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Rett syndrome is characterized by the development of stereotypic hand movements and seizures, which are often difficult to treat. Previous studies have shown conflicting results during add-on folinic acid. Here, the authors reevaluate the response to folinic acid in terms of epilepsy control and electroencephalography features. They performed a randomized, placebo-controlled, double-blind crossover trial, with a follow-up of more than 2 years. Twelve girls with Rett syndrome participated, comparable in clinical stage and disease severity. The Rett syndrome patients were given either folinic acid or placebo, for 1 year each. Only 3 girls benefited to some extent: 2 had a reduction and/or decrease in seizures, and all 3 showed some decreased epileptiform activity on electroencephalography during the addition of folinic acid. Despite this, antiepileptic drugs were adjusted. Because the effect of added folinic acid was limited and did not prevent antiepileptic drug increase, the authors do not recommend adding on folinic acid in Rett syndrome girls with epilepsy. |
| | |
Authors:
|
Eveline E O Hagebeuk; Johannes H T M Koelman; Marinus Duran; Nico G Abeling; Arno Vyth; Bwee-Tien Poll-The |
Related Documents
:
|
9473803 - Therapeutic plasma exchange in neurologic disorders. 19096143 - Foreign accent syndrome mimicked by garcin syndrome with spontaneous resolution. 6967133 - Interstitial nephritis in a patient with atypical sjögren's syndrome. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-22 |
Journal Detail:
|
Title: Journal of child neurology Volume: - ISSN: 1708-8283 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-23 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8606714 Medline TA: J Child Neurol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Academical Medical Center, Department of Paediatric Neurology, Amsterdam, the Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Survey of Aspirin Use in Sturge-Weber Syndrome.
Next Document: Neurocysticercosis-Induced Hemiballismus in a Child.