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Clinical Efficacy of Subgingivally Delivered 1.2% Atorvastatin in Chronic Periodontitis: A Randomized Controlled Clinical Trial.
MedLine Citation:
PMID:  23030241     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: Atorvastatin (ATV) is a specific competitive inhibitor of 3-hydroxy-2-methyl-glutaryl coenzyme A reductase. Recently, statins have shown pleiotropic effects like antiinflammation and bone stimulation. The aim of the present study was to investigate the effectiveness of 1.2 % ATV, as an adjunct to scaling and root planing (SRP) in the treatment of intrabony defects. Methods: 60 individuals were randomized and categorized into two treatment groups: SRP plus 1.2% ATV and SRP plus placebo gel. Clinical parameters were recorded at baseline and at 3, 6 and 9 months which included modified sulcus bleeding index (mSBI), probing depth (PD), and clinical attachment level (CAL) at baseline, after 6 months and 9 months and radiologic assessment of intrabony defect (IBD) fill was done using computer-aided software at baseline, 6 and 9 months. Results: Mean probing depth reduction and mean clinical attachment level gain was found to greater in ATV group than placebo group, at 3, 6 and 9 months. Furthermore, significantly greater mean percentage of radiographic bone fill was found in the ATV group (35.49±5.50%) compared to placebo group (1.82±1.32%) after 9 months. Conclusion: ATV can provide a new direction in the management of intrabony defects as an adjunct to SRP.
Authors:
A R Pradeep; Minal Kumari; Nishanth S Rao; Santosh S Martande; Savitha B Naik
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-2
Journal Detail:
Title:  Journal of periodontology     Volume:  -     ISSN:  1943-3670     ISO Abbreviation:  J. Periodontol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000345     Medline TA:  J Periodontol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Periodontics, Government Dental College & Research, Institute, Bangalore 560002.
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