Document Detail


Clinical efficacy of sildenafil in treatment of pulmonary arterial hypertension in dogs.
MedLine Citation:
PMID:  20412435     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Pulmonary arterial hypertension (PAH) in dogs carries a poor prognosis. Sildenafil increases exercise capacity and improves hemodynamics in people with PAH. HYPOTHESIS/OBJECTIVES: Dogs receiving sildenafil will have lower pulmonary arterial pressure, increased exercise capacity, and better quality of life (QOL) than dogs receiving placebo. ANIMALS: Thirteen dogs with echocardiographic evidence of PAH. METHODS: Prospective short-term, randomized, placebo controlled, double-blind, crossover study. Dogs with PAH were randomly allocated to receive sildenafil or placebo for 4 weeks, followed by the alternative treatment for 4 weeks. RESULTS: Dogs receiving sildenafil had a significantly lower estimated pulmonary arterial pressure (median, 56 mmHg; range, 34-83 mmHg) than at baseline (median, 72 mmHg; range, 61-86 mmHg; P=.018), but not significantly lower than those receiving placebo (median, 62 mmHg; range, 49-197 mmHg). Exercise capacity was significantly greater in dogs receiving sildenafil than those receiving placebo (mean activity count per minute: 101+/-47 versus 74+/-32; P=.05). QOL scores were significantly higher in dogs receiving sildenafil than dogs receiving placebo. CONCLUSIONS AND CLINICAL IMPORTANCE: Sildenafil decreases systolic pulmonary arterial pressure from baseline in dogs with PAH and is associated with increased exercise capacity and QOL when compared to treatment with placebo.
Authors:
A J Brown; E Davison; M M Sleeper
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-04-16
Journal Detail:
Title:  Journal of veterinary internal medicine / American College of Veterinary Internal Medicine     Volume:  24     ISSN:  0891-6640     ISO Abbreviation:  J. Vet. Intern. Med.     Publication Date:    2010 Jul-Aug
Date Detail:
Created Date:  2010-07-23     Completed Date:  2010-09-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8708660     Medline TA:  J Vet Intern Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  850-4     Citation Subset:  IM    
Affiliation:
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA. andrewjb@msu.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Cross-Over Studies
Dogs
Double-Blind Method
Female
Hypertension, Pulmonary / drug therapy,  veterinary*
Male
Piperazines / therapeutic use*
Purines / therapeutic use
Sulfones / therapeutic use*
Vasodilator Agents / therapeutic use*
Chemical
Reg. No./Substance:
0/Piperazines; 0/Purines; 0/Sulfones; 0/Vasodilator Agents; 139755-83-2/sildenafil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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