| Clinical effects and lethal and forensic aspects of propofol. | |
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MedLine Citation:
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PMID: 20950316 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Propofol is a potent intravenous anesthetic agent that rapidly induces sedation and unconsciousness. The potential for propofol dependency, recreational use, and abuse has only recently been recognized, and several cases of accidental overdose and suicide have emerged. In addition, the first documented case of murder using propofol was reported a few months ago, and a high profile case of suspected homicide with propofol is currently under investigation. A number of analytical methods have been employed to detect and quantify propofol concentrations in biological specimens. The reported propofol-related deaths and postmortem blood and tissue levels are reviewed. Importantly, limitations of propofol detection are discussed, and future considerations are presented. Because propofol has the potential for diversion with lethal consequences, the forensic scientist must have a basic understanding of its clinical indications and uses, pharmacologic properties, and detection methods. In addition, medical institutions should develop systems to prevent and detect diversion of this potential drug of abuse. |
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Authors:
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Richard J Levy |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2010-10-15 |
Journal Detail:
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Title: Journal of forensic sciences Volume: 56 Suppl 1 ISSN: 1556-4029 ISO Abbreviation: J. Forensic Sci. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-04 Completed Date: 2011-05-31 Revised Date: 2011-09-22 |
Medline Journal Info:
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Nlm Unique ID: 0375370 Medline TA: J Forensic Sci Country: United States |
Other Details:
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Languages: eng Pagination: S142-7 Citation Subset: IM |
Copyright Information:
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© 2010 American Academy of Forensic Sciences. |
Affiliation:
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Children's National Medical Center, The George Washington University School of Medicine and Health Sciences, Washington, DC 20010. rlevy@cnmc.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Accidents* Acidosis / chemically induced Acute Kidney Injury / chemically induced Bacteremia / chemically induced Bradycardia / chemically induced Dyslipidemias / chemically induced Forensic Toxicology Health Personnel Heart Arrest / chemically induced Heart Failure / chemically induced Homicide* Humans Hypertriglyceridemia / chemically induced Hypnotics and Sedatives / blood, chemistry, pharmacology* Hypotension / chemically induced Molecular Structure Overdose Pancreatitis / chemically induced Propofol / blood, chemistry, pharmacology* Rhabdomyolysis / chemically induced Sepsis / chemically induced Substance Abuse Detection / methods Substance-Related Disorders / complications* Suicide* Syndrome |
| Grant Support | |
ID/Acronym/Agency:
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5K08GM074117-04/GM/NIGMS NIH HHS; K08 GM074117-07/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hypnotics and Sedatives; 2078-54-8/Propofol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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