Document Detail


Clinical effects and lethal and forensic aspects of propofol.
MedLine Citation:
PMID:  20950316     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Propofol is a potent intravenous anesthetic agent that rapidly induces sedation and unconsciousness. The potential for propofol dependency, recreational use, and abuse has only recently been recognized, and several cases of accidental overdose and suicide have emerged. In addition, the first documented case of murder using propofol was reported a few months ago, and a high profile case of suspected homicide with propofol is currently under investigation. A number of analytical methods have been employed to detect and quantify propofol concentrations in biological specimens. The reported propofol-related deaths and postmortem blood and tissue levels are reviewed. Importantly, limitations of propofol detection are discussed, and future considerations are presented. Because propofol has the potential for diversion with lethal consequences, the forensic scientist must have a basic understanding of its clinical indications and uses, pharmacologic properties, and detection methods. In addition, medical institutions should develop systems to prevent and detect diversion of this potential drug of abuse.
Authors:
Richard J Levy
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2010-10-15
Journal Detail:
Title:  Journal of forensic sciences     Volume:  56 Suppl 1     ISSN:  1556-4029     ISO Abbreviation:  J. Forensic Sci.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-04     Completed Date:  2011-05-31     Revised Date:  2014-09-05    
Medline Journal Info:
Nlm Unique ID:  0375370     Medline TA:  J Forensic Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S142-7     Citation Subset:  IM    
Copyright Information:
© 2010 American Academy of Forensic Sciences.
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MeSH Terms
Descriptor/Qualifier:
Accidents*
Acidosis / chemically induced
Acute Kidney Injury / chemically induced
Bacteremia / chemically induced
Bradycardia / chemically induced
Drug Overdose
Dyslipidemias / chemically induced
Forensic Toxicology
Health Personnel
Heart Arrest / chemically induced
Heart Failure / chemically induced
Homicide*
Humans
Hypertriglyceridemia / chemically induced
Hypnotics and Sedatives / blood,  chemistry,  pharmacology*
Hypotension / chemically induced
Molecular Structure
Pancreatitis / chemically induced
Propofol / blood,  chemistry,  pharmacology*
Rhabdomyolysis / chemically induced
Sepsis / chemically induced
Substance Abuse Detection / methods
Substance-Related Disorders / complications*
Suicide*
Syndrome
Grant Support
ID/Acronym/Agency:
5K08GM074117-04/GM/NIGMS NIH HHS; K08 GM074117/GM/NIGMS NIH HHS; K08 GM074117-07/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Hypnotics and Sedatives; YI7VU623SF/Propofol
Comments/Corrections

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