Document Detail

Clinical and echographic analysis of ablative fractionated carbon dioxide laser in the treatment of photodamaged facial skin.
MedLine Citation:
PMID:  21040129     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Ablative fractional photothermolysis (AFP) has been reported to be effective in the treatment of photoaging.
MATERIALS AND METHODS: Treatment was administered using an AFP device and assessed photographically 3 months after treatment by a blinded physician. Ultrasound measurements evaluated skin thickness and subepidermal low echogenic band thickness (SLEB), the portion of the papillary dermis filled with solar elastosis.
RESULTS: Three months after treatment, the mean score improved 61.0% (95% confidence interval (CI)=56.8-65.2%) for dyschromia, 54.3% (95% CI=51.6-57.0%) for skin laxity, 51.5% (95% CI=49.6-53.4%) for rhytides, and 60.2%9 (95% CI=56.8-63.6%) for overall cosmetic outcome. Patients had a significant decrease in SLEB in all anatomic sites treated (0.078 cm at baseline, 0.038 cm at 3 months, 40.0% decrease) (p<.001). Total skin thickness increased with AFP (0.163 cm at baseline, 0.188 cm at 3 months, 10.3% increase) (p<.05).
CONCLUSIONS: In this pilot study, AFP improved pigmentary and textural components of photoaged skin. Future investigation is warranted to validate the results demonstrating that high resolution ultrasound can be used as a quantitative tool to assess skin changes after AFP.
Emily P Tierney; C William Hanke; Jeffrey Petersen; Ted Bartley; James R Eckert; Carolyn McCutchen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-11
Journal Detail:
Title:  Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]     Volume:  36     ISSN:  1524-4725     ISO Abbreviation:  Dermatol Surg     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-03     Completed Date:  2011-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9504371     Medline TA:  Dermatol Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2009-21     Citation Subset:  IM    
Copyright Information:
© 2010 by the American Society for Dermatologic Surgery, Inc.
Laser and Skin Surgery Center of Indiana, Carmel, IN, USA.
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MeSH Terms
Carbon Dioxide
Cosmetic Techniques / instrumentation*
Facial Dermatoses / radiotherapy*
Laser Therapy / instrumentation
Middle Aged
Pilot Projects
Prospective Studies
Skin Aging*
Treatment Outcome
Reg. No./Substance:
124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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