Document Detail


Clinical Diagnostic Gene Expression Thyroid Testing.
MedLine Citation:
PMID:  25041959     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Thyroid fine-needle aspiration biopsies are cytologically indeterminate in 15% to 30% of cases. When cytologically indeterminate thyroid nodules undergo diagnostic surgery, approximately three-quarters prove to be histologically benign. A negative predictive value of more than or equal to 94% for the Afirma Gene Expression Classifier (GEC) is achieved for indeterminate nodules. Most Afirma GEC benign nodules can be clinically observed, as suggested by the National Comprehensive Cancer Network Thyroid Carcinoma Guideline. More than half of the benign nodules with indeterminate cytology (Bethesda categories III/IV) can be identified as GEC benign and removed from the surgical pool to prevent unnecessary diagnostic surgery.
Authors:
David L Steward; Richard T Kloos
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Publication Detail:
Type:  REVIEW    
Journal Detail:
Title:  Otolaryngologic clinics of North America     Volume:  47     ISSN:  1557-8259     ISO Abbreviation:  Otolaryngol. Clin. North Am.     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-7-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0144042     Medline TA:  Otolaryngol Clin North Am     Country:  -    
Other Details:
Languages:  ENG     Pagination:  573-593     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Inc. All rights reserved.
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