Document Detail

Clinical course of arrhythmogenic right ventricular cardiomyopathy in the era of implantable cardioverter-defibrillators and radiofrequency catheter ablation.
MedLine Citation:
PMID:  20145349     Owner:  NLM     Status:  MEDLINE    
This study investigated the clinical course of arrhythmogenic right ventricular cardiomyopathy (ARVC) patients and in particular evaluated the contribution of radiofrequency catheter ablation (RFCA) and an implantable cardioverter-defibrillator (ICD) to the treatment of ARVC. ARVC is a myocardial disorder and a cause of sudden cardiac death due to ventricular tachycardia (VT). Little is known about its prognosis in Japanese ARVC patients. Thirty-five ARVC patients were studied. Mean age of patients whose onset of ARVC was congestive heart failure (CHF) (66.0 +/- 4.0 years) was significantly higher than those whose onset was VT (44.5 +/- 14.8 years, P < 0.05). ARVC patients with CHF onset showed significantly higher death rates compared to those with VT onset. ICD treatment significantly reduced episodes of hospitalization due to VT (0.1 +/- 0.4 episodes) in comparison to treatment by RFCA (1.7 +/- 2.2 episodes, P < 0.03). RFCA treatment did not reduce recurrence of VT in the follow-up period. ICD therapy showed comparable mortality to RFCA treatment. The prognosis of ARVC with CHF onset is poor. ICD therapy significantly reduced hospitalization due to VT compared with RFCA treatment. ICD implantation in combination with medication may be a better treatment for ARVC.
Masatoshi Komura; Jun-Ichi Suzuki; Susumu Adachi; Atsushi Takahashi; Kenichiro Otomo; Junichi Nitta; Mitsuhiro Nishizaki; Tohru Obayashi; Akihiko Nogami; Yasuhiro Satoh; Kaoru Okishige; Hitoshi Hachiya; Kenzo Hirao; Mitsuaki Isobe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International heart journal     Volume:  51     ISSN:  1349-2365     ISO Abbreviation:  Int Heart J     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-10     Completed Date:  2010-03-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101244240     Medline TA:  Int Heart J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  34-40     Citation Subset:  IM    
Department of Cardiovascular Medicine, Tokyo Medical and Dental University Hospital.
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MeSH Terms
Anti-Arrhythmia Agents / therapeutic use
Arrhythmogenic Right Ventricular Dysplasia / complications*,  drug therapy,  surgery
Catheter Ablation*
Defibrillators, Implantable*
Heart Failure / etiology*
Middle Aged
Retrospective Studies
Tachycardia, Ventricular / etiology*,  therapy
Treatment Outcome
Young Adult
Reg. No./Substance:
0/Anti-Arrhythmia Agents

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