Document Detail

Clinical comparison of 12 mg ropivacaine and 8 mg bupivacaine, both with 20 microg fentanyl, in spinal anaesthesia for major orthopaedic surgery in geriatric patients.
MedLine Citation:
PMID:  20134178     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study was to compare the haemodynamic and anaesthetic effects of 12 mg ropivacaine and 8 mg bupivacaine, both with 20 microg fentanyl, in spinal anaesthesia for major orthopaedic surgery in geriatric patients. SUBJECTS AND METHODS: Sixty American Society of Anesthesiologists (ASA) II-III patients scheduled for hip arthroplasty were randomly assigned to receive an intrathecal injection of either 12 mg ropivacaine with 20 microg fentanyl (group R, aged 70 +/- 7 years, range 67-89) or 8 mg hyperbaric bupivacaine with 20 microg fentanyl (group B, aged 69 +/- 6 years, range 66-92). Motor and sensory block, haemodynamics and side effects were recorded. RESULTS: Mean levels of sensory block were similar, but the onset time of sensory block in group B (2.52 +/- 0.69 min) was shorter than that in group R (3.17-0.72 min); the difference was statistically significant (p < 0.01), and the number of patients who had motor Bromage scale 3 in group B (24) was greater than in group R (16). The difference was also statistically significant (p < 0.05). Systolic and diastolic arterial pressures (SAP, DAP) and heart rate (HR) decreased after the block in both groups. SAP (after the 60th and 120th min of block), DAP (all measurement times), and HR (after the 20th, 25th and 30th min of block) were lower in group B than in group R. CONCLUSIONS: The data showed that 12 mg of ropivacaine and 8 mg of bupivacaine with 20 microg fentanyl in spinal anaesthesia can provide sufficient motor and sensory block for major orthopaedic surgery in geriatric patients. However, ropivacaine caused less motor block and haemodynamic side effects than bupivacaine during the procedure.
Engin Erturk; Cigdem Tutuncu; Ahmet Eroglu; Merih Gokben
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2010-02-04
Journal Detail:
Title:  Medical principles and practice : international journal of the Kuwait University, Health Science Centre     Volume:  19     ISSN:  1423-0151     ISO Abbreviation:  Med Princ Pract     Publication Date:  2010  
Date Detail:
Created Date:  2010-02-05     Completed Date:  2010-05-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8901334     Medline TA:  Med Princ Pract     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  142-7     Citation Subset:  IM    
Copyright Information:
Copyright 2010 S. Karger AG, Basel.
Faculty of Medicine, Department of Anaesthesiology and Intensive Care, Karadeniz Technical University, Trabzon, Turkey.
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MeSH Terms
Aged, 80 and over
Amides / administration & dosage,  pharmacology*
Analysis of Variance
Anesthesia Recovery Period
Anesthesia, Spinal / methods*
Anesthetics, Intravenous / administration & dosage,  pharmacology*
Anesthetics, Local / administration & dosage,  pharmacology*
Arthroplasty, Replacement, Hip
Bupivacaine / administration & dosage,  pharmacology*
Double-Blind Method
Fentanyl / administration & dosage,  pharmacology*
Hemodynamics / drug effects
Hip Joint / surgery
Nerve Block / methods
Orthopedic Procedures
Reg. No./Substance:
0/Amides; 0/Anesthetics, Intravenous; 0/Anesthetics, Local; 2180-92-9/Bupivacaine; 437-38-7/Fentanyl; 84057-95-4/ropivacaine

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