Document Detail


Clinical characteristics and reproductive outcomes in infertile men with testicular early and late maturation arrest.
MedLine Citation:
PMID:  22950993     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To compare the clinical characteristics and reproductive outcomes of nonobstructive azoospermic men with uniform early and late maturation arrest.
METHODS: Patients with biopsy-documented uniform maturation arrest undergoing testicular sperm retrieval and complete medical records were enrolled in the present study. Their medical history, physical examination findings, testicular volume, serum hormone parameters, genetic anomalies, sperm retrieval, and reproductive outcomes were retrospectively analyzed.
RESULTS: In a cohort of 223 nonobstructive azoospermic men, 34 men with uniform maturation arrest (21 early maturation arrest and 13 late maturation arrest) were identified. No significant differences were seen in the age distribution, testicular volume, or hormone parameters between patients with early and late maturation arrest. Only 13 patients (38.2%) had a normal serum follicle-stimulating hormone level and normal testicular volume. Patients with early maturation arrest had a greater frequency of overall genetic anomalies, and patients with late maturation arrest had a greater frequency of previous testicular insults. The sperm retrieval and impregnation rate were nonsignificantly greater in patients with late maturation arrest.
CONCLUSION: Maturation arrest has a variety of causes and presents with diverse phenotypes. Not all patients with uniform maturation arrest have a normal follicle-stimulating hormone level or testicular volume. Patients with early maturation arrest have a greater incidence of genetic anomalies and are more likely to have worse reproductive outcomes than are patients with late maturation arrest.
Authors:
Ming-Chun Tsai; Yu-Sheng Cheng; Tsung-Yen Lin; Wen-Horng Yang; Yung-Ming Lin
Related Documents :
7555423 - Internal rectal intussusception--fact or fancy?
20082543 - Malignant colonic adenomas. therapeutic criteria. long-term results of therapy in a ser...
12360173 - Septal q waves as an indicator of risk of mortality in elderly patients with chronic he...
Publication Detail:
Type:  Journal Article     Date:  2012-08-28
Journal Detail:
Title:  Urology     Volume:  80     ISSN:  1527-9995     ISO Abbreviation:  Urology     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-01     Completed Date:  2012-12-31     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  0366151     Medline TA:  Urology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  826-32     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Department of Urology, National Cheng Kung University Hospital, National Cheng Kung University College of Medicine, Tainan, Taiwan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Azoospermia / etiology*,  genetics
Female
Follicle Stimulating Hormone / blood
Humans
Karyotype
Male
Middle Aged
Organ Size
Pregnancy
Pregnancy Rate*
Retrospective Studies
Sexual Maturation / genetics
Sperm Injections, Intracytoplasmic
Sperm Retrieval
Testis / growth & development,  pathology,  physiopathology*
Chemical
Reg. No./Substance:
9002-68-0/Follicle Stimulating Hormone
Comments/Corrections
Comment In:
J Urol. 2013 Jun;189(6):2260-1   [PMID:  23663639 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The effect of 5-aminolevulinic acid and its derivatives on protoporphyrin IX accumulation and apopto...
Next Document:  Assessment of Rates of Lymph Nodes and Lymph Node Metastases in Periprostatic Fat Pads in a Consecut...