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Clinical Characteristics Of Neonates With VACTERL Association.
MedLine Citation:
PMID:  22300427     Owner:  NLM     Status:  Publisher    
Background:  The VACTERL association (VA) is the nonrandom co-occurrence of Vertebral anomalies, Anal atresia, Cardiovascular malformations, Tracheo-esophageal fistula and/or Esophageal atresia, Renal anomalies, and/or Limb-anomalies, and is referred to the first letters of its components. Studies investigating the clinical characteristics of VA patients and probing of the observed current six component types are limited, and none of them is focused to neonates. Clinical characteristics of our patients diagnosed as having VA in the newborn period is investigated. Methods:  We retrospectively reviewed the neonates whose final diagnosis was VACTERL association. Presence of at least 3 components of previously reported 6 anomalies was accepted as VACTERL association. Gender, birth weight, gestational age, postnatal age, anomalies of the systems that are included into the VA, and the other features are recorded. Results:  There was a male predominance (14/11) of 28 patients. And, there were three patients with ambiguous genitalia. The most common observed VACTERL component was vertebral anomalies (n = 26), followed by anal atresia (n = 19), TEF/EA (n = 17), renal anomalies (n = 15), limb anomalies (n = 15) and cardiac anomalies (n = 14). The most frequent combination was VCTL (n = 4). Fifteen (57%) patients had non-VACTERL anomalies and the most frequent one was ambiguous genitalia (n = 3). Conclusıon:  VA patients may have different clinical characteristics in different populations, and one may miss some component features if the patients are evaluated after neonatal period. © 2012 The Authors. Pediatrics International © 2012 Japan Pediatric Society.
Oral Akgun; Caner Ibrahim; Yigiter Murat; Kantarci Mecit; Olgun Hasim; Ceviz Naci; Salman Ahmet Bedii
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-2
Journal Detail:
Title:  Pediatrics international : official journal of the Japan Pediatric Society     Volume:  -     ISSN:  1442-200X     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886002     Medline TA:  Pediatr Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. Pediatrics International © 2012 Japan Pediatric Society.
Department of Pediatric Surgery, Faculty of Medicine, Ataturk University, Turkey, Erzurum Department of Pediatrics, Division of Neonatology, Faculty of Medicine, Ataturk University, Turkey, Erzurum Department of Radiology, Faculty of Medicine, Ataturk University, Turkey, Erzurum Department of Pediatrics, Division of Pediatric Cardiology, Ataturk University, Turkey, Erzurum.
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