Document Detail


Clinical Characteristics and Circumstances of Death in the Sudden Arrhythmic Death Syndrome.
MedLine Citation:
PMID:  25262685     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: -Sudden cardiac death (SCD) is a devastating event in the young. Referral to a specialist cardiac pathologist is recommended. Age, sex and circumstances of death may reflect underlying diagnoses. We aim to describe the demographics of victims and circumstances surrounding SCD with a normal heart (i.e. Sudden Arrhythmic Death Syndrome (SADS)).
METHODS AND RESULTS: -There were 2156 cases of SCD from across the United Kingdom referred to a tertiary cardiac pathology service from 1994-2010. We analysed 967 consecutive cases (61% male; median age 29 years) with a normal heart at post-mortem. Information from referring coroners' reports was used to ascertain clinical information. Familial evaluation was carried out in 5% of cases. Information from these cases was used to determine the likely accuracy of coronial reports. Deaths during sleep or at rest were more common than deaths during exercise or with emotional stress: 82% vs. 16%. Death with exercise/stress was more common in males (RR 2.33, 95% CI 1.56-3.47, p<0.001) and those under 18 (males: RR 2.41 (95%CI 1.69-3.13, p<0.001), females: RR 2.91 (95%CI 1.80-4.01, p<0.001)). Prior syncope (4.1%), documented arrhythmia (3.4%) and family history of sudden death (4.2%) were uncommon. Epilepsy had been diagnosed in 6.6%.
CONCLUSIONS: -Death due to SADS is more common at rest or during sleep. Death with exercise/stress is more common in males and those aged below 18 years. Up to 90% of SADS victims have no preceding symptoms or recognised risk factors for sudden death. Epilepsy may be considered a risk factor for SADS.
Authors:
Greg Mellor; Hariharan Raju; Sofia V de Noronha; Michael Papadakis; Sanjay Sharma; Elijah R Behr; Mary N Sheppard
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-28
Journal Detail:
Title:  Circulation. Arrhythmia and electrophysiology     Volume:  -     ISSN:  1941-3084     ISO Abbreviation:  Circ Arrhythm Electrophysiol     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-29     Completed Date:  -     Revised Date:  2014-9-30    
Medline Journal Info:
Nlm Unique ID:  101474365     Medline TA:  Circ Arrhythm Electrophysiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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