Document Detail


Clinical benefit of low molecular weight heparin for ST-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention with glycoprotein IIb/IIIa inhibitor.
MedLine Citation:
PMID:  21060749     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The efficacy of low molecular weight heparin (LMWH) with low dose unfractionated heparin (UFH) during percutaneous coronary intervention (PCI) with or without glycoprotein (Gp) IIb/IIIa inhibitor compared to UFH with or without Gp IIb/IIIa inhibitor has not been elucidated. Between October 2005 and July 2007, 2,535 patients with ST elevation acute myocardial infarction (STEMI) undergoing PCI in the Korean Acute Myocardial Infarction Registry (KAMIR) were assigned to either of two groups: a group with Gp IIb/IIIa inhibitor (n=476) or a group without Gp IIb/IIIa inhibitor (n=2,059). These groups were further subdivided according to the use of LMWH with low dose UFH (n=219) or UFH alone (n=257). The primary end points were cardiac death or myocardial infarction during the 30 days after the registration. The primary end point occurred in 4.1% (9/219) of patients managed with LMWH during PCI and Gp IIb/IIIa inhibitor and 10.8% (28/257) of patients managed with UFH and Gp IIb/IIIa inhibitor (odds ratio [OR], 0.290; 95% confidence interval [CI], 0.132-0.634; P=0.006). Thrombolysis In Myocardial Infarction (TIMI) with major bleeding was observed in LMHW and UFH with Gp IIb/IIIa inhibitor (1/219 [0.5%] vs 1/257 [0.4%], P=1.00). For patients with STEMI managed with a primary PCI and Gp IIb/IIIa inhibitor, LMWH is more beneficial than UFH.
Authors:
Jung Sun Cho; Sung-Ho Her; Ju Yeal Baek; Mahn-Won Park; Hyoung Doo Kim; Myung Ho Jeong; Young keun Ahn; Shung Chull Chae; Seung Ho Hur; Taek Jong Hong; Young Jo Kim; In Whan Seong; Jei Keon Chae; Jay Young Rhew; In Ho Chae; Myeong Chan Cho; Jang Ho Bae; Seung Woon Rha; Chong Jim Kim; Donghoon Choi; Yang Soo Jang; Junghan Yoon; Wook Sung Chung; Jeong Gwan Cho; Ki Bae Seung; Seung Jung Park;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-26
Journal Detail:
Title:  Journal of Korean medical science     Volume:  25     ISSN:  1598-6357     ISO Abbreviation:  J. Korean Med. Sci.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-09     Completed Date:  2011-04-07     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  8703518     Medline TA:  J Korean Med Sci     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  1601-8     Citation Subset:  IM    
Affiliation:
Cardiovascular Center, Seoul St. Mary's Hospital, Seoul, Korea.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Aged
Drug Therapy, Combination
Female
Hemorrhage
Heparin / therapeutic use*
Heparin, Low-Molecular-Weight / therapeutic use*
Humans
Male
Middle Aged
Multivariate Analysis
Myocardial Infarction / epidemiology,  mortality,  therapy*
Myocardial Revascularization
Odds Ratio
Platelet Glycoprotein GPIIb-IIIa Complex / antagonists & inhibitors*,  metabolism
Prognosis
Registries
Chemical
Reg. No./Substance:
0/Heparin, Low-Molecular-Weight; 0/Platelet Glycoprotein GPIIb-IIIa Complex; 9005-49-6/Heparin
Investigator
Investigator/Affiliation:
Myung Ho Jeong / ; Young Jo Kim / ; Chong Jin Kim / ; Myeong Chan Cho / ; Young Keun Ahn / ; Jong Hyun Kim / ; Shung Chull Chae / ; Seung Ho Hur / ; In Whan Seong / ; Taek Jong Hong / ; Dong Hoon Choi / ; Jei Keon Chae / ; Jae Young Rhew / ; Doo Il Kim / ; In Ho Chae / ; Junghan Yoon / ; Bon Kwon Koo / ; Byung Ok Kim / ; Myoung Yong Lee / ; Kee Sik Kim / ; Jin Yong Hwang / ; Seok Kyu Oh / ; Nae Hee Lee / ; Kyoung Tae Jeong / ; Seung Jea Tahk / ; Jang Ho Bae / ; Seung Woon Rha / ; Keum Soo Park / ; Kyoo Rok Han / ; Tae Hoon Ahn / ; Moo Hyun Kim / ; Joo Young Yang / ; Chong Yun Rhim / ; Hyeon Cheol Gwon / ; Seong Wook Park / ; YoungYoup Koh / ; Seung Jae Joo / ; Soo Joong Kim / ; Dong Kyu Jin / ; Jin Man Cho / ; Wook Sung Chung / ; Yang Soo Jang / ; Jeong Gwan Cho / ; Ki Bae Seung / ; Seung Jung Park /
Comments/Corrections

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