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Clinical Associations with a Placental Diagnosis of Delayed Villous Maturation: A Retrospective Study.
MedLine Citation:
PMID:  21329421     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Objective: Delayed villous maturation (DVM) is a spectrum of placental disease characterised by decreased tertiary villus formation, reduced vasculosyncytial membrane formation and, in the more severe grades, increased large bullous villi. In some series it is associated with an increased risk of stillbirth in the late third trimester, but overall there is little data on its significance. The aim of this study was to assess perinatal factors associated with, and the clinical significance of, the finding of DVM on placental histology. Methods: This was a retrospective study investigating all pregnancies with DVM diagnosed on placental histology in a tertiary level unit from December 2001 to August 2006. Over 6 years 2,915 placentas were triaged for histopathological assessment, representing 6.1% of all 48,054 deliveries in this time period. One hundred and ninety (6.3%) of these selected cases showed DVM. Fifteen placentas less than 34 completed weeks gestation were excluded, leaving 175 for further analysis. Principal Results: When compared with controls matched for gestation and delivering within the same time period (n=175), DVM was significantly associated with pre-gestational diabetes (8% vs 2.8%, p<0.05; RR 2.8 (95% CI 1.03-7.6)), gestational diabetes (8.6% vs 3.4%, p<0.05; RR 2.5 95% CI 0.99-6.3), and antenatal or intrapartum intrauterine death (8.6% vs 0%, p<0.05).Conclusion: DVM is associated with both gestational and pre-gestational diabetes mellitus and with perinatal death.
Authors:
Mary F Higgins; Fionnuala M McAuliffe; Eoghan Mooney
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-17
Journal Detail:
Title:  Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society     Volume:  -     ISSN:  1093-5266     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9809673     Medline TA:  Pediatr Dev Pathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1 School of Medicine and Medical Science.
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