Document Detail

Clinic experience of prenatal diagnosis of cystic fibrosis by use of linked DNA probes.
MedLine Citation:
PMID:  2888995     Owner:  NLM     Status:  MEDLINE    
96 families at risk of having a child with cystic fibrosis have been counselled about prenatal diagnosis by the use of linked DNA probes. Of the first 30 pregnancies 9 children have been born and confirmed to be free from CF, as predicted; 8 pregnancies were terminated (1 of these was found to be miscarrying at time of termination); 12 pregnancies, in which the fetuses are predicted to be unaffected, are in progress; and 1 has miscarried. No couple with a prenatal prediction of CF decided to continue with the pregnancy. 1 pregnancy was terminated because of a 50:50 chance of an affected fetus. In 1 twin pregnancy the affected fetus was selectively aborted, and the other baby was confirmed after birth to be unaffected, as predicted. In the other twin pregnancy the two chorionic plates could not be samples separately; the pregnancy was continued on the basis of normal findings for the lower plate, and both twins have turned out to be normal. Many couples at risk see early prenatal diagnosis as a way to help them have an unaffected child.
M Super; A Ivinson; M Schwarz; L Giles; R G Elles; A P Read; R Harris
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lancet     Volume:  2     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1987-11-03     Completed Date:  1987-11-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  782-4     Citation Subset:  AIM; IM    
Clinical Genetics Unit, Royal Manchester Children's Hospital.
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MeSH Terms
Abortion, Induced
Abortion, Spontaneous / etiology
Chorionic Villi / ultrastructure
Cystic Fibrosis / diagnosis*,  genetics
DNA / isolation & purification
Genetic Counseling
Genetic Markers*
Pregnancy, Multiple
Prenatal Diagnosis / methods*
Reg. No./Substance:
0/Genetic Markers; 9007-49-2/DNA
Erratum In:
Lancet 1987 Oct 17;2(8564):926

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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