| Clindamycin and taste disorders. | |
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MedLine Citation:
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PMID: 17635503 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: Topical use of clindamycin has been associated with taste disorders in the literature, but little is known about the nature of this adverse drug reaction. The aim of this article was to describe reports of clindamycin-induced taste disorders and to analyse the factors involved. METHODS: The adverse drug reaction database of the Netherlands Pharmacovigilance Centre was searched for reports concerning taste disorders with antibiotics. Clinical review of the cases and statistical analysis with logistic regression were performed. Characteristics of patients who reported taste disorders were compared for age, gender and formulation in clindamycin vs. other antibiotic users. RESULTS: Taste disorders were reported in seven (18%) of the clindamycin cases. In five reports an oral formulation was involved, in one report intravenous (i.v.) administration and in one report both formulations were used. Latency was <1 day after start and in one case taste disorders were present repeatedly at 10 min after every i.v. application. The adjusted reporting odds ratio was 7.0 (95% confidence interval 2.8, 17.3) and supports a possible causal relationship. CONCLUSIONS: The association of clindamycin and taste disorders is supported by disproportionality analysis and seems to be independent of possible confounders such as age, gender and infections. The case reports suggest a role for clindamycin concentrations excreted in body fluids like saliva. |
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Authors:
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Mark C H de Groot; Eugène P van Puijenbroek |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2007-07-17 |
Journal Detail:
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Title: British journal of clinical pharmacology Volume: 64 ISSN: 0306-5251 ISO Abbreviation: Br J Clin Pharmacol Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-09-20 Completed Date: 2008-03-14 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: England |
Other Details:
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Languages: eng Pagination: 542-5 Citation Subset: IM |
Affiliation:
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Netherlands Pharmacovigilance Centre Lareb, 's-Hertogenbosch, The Netherlands. m.degroot@lareb.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Anti-Bacterial Agents / administration & dosage, adverse effects*, therapeutic use Clindamycin / administration & dosage, adverse effects*, therapeutic use Drug Administration Routes Female Humans Male Middle Aged Netherlands Odds Ratio Taste Disorders / chemically induced* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 18323-44-9/Clindamycin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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