Document Detail


Click and pick: identification of sialoside analogues for siglec-based cell targeting.
MedLine Citation:
PMID:  23038623     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Click 'n' chips: Azide and alkyne-bearing sialic acids (purple diamond; see picture) were subjected to high-throughput click chemistry to generate a library of sialic acid analogues. Microarray printing of the library and screening with the siglec family of sialic-acid-binding proteins, led to the identification of high-affinity ligands for siglec-9 and siglec-10.
Authors:
Cory D Rillahan; Erik Schwartz; Ryan McBride; Valery V Fokin; James C Paulson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-10-04
Journal Detail:
Title:  Angewandte Chemie (International ed. in English)     Volume:  51     ISSN:  1521-3773     ISO Abbreviation:  Angew. Chem. Int. Ed. Engl.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-25     Completed Date:  2013-01-22     Revised Date:  2013-11-04    
Medline Journal Info:
Nlm Unique ID:  0370543     Medline TA:  Angew Chem Int Ed Engl     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  11014-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Department of Chemical Physiology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
CHO Cells
Carbohydrate Conformation
Cell Line
Click Chemistry
Cricetinae
Humans
Leukocytes, Mononuclear / cytology*
Mice
N-Acetylneuraminic Acid / analogs & derivatives,  chemical synthesis,  chemistry*
Protein Array Analysis
Sialic Acid Binding Immunoglobulin-like Lectins / chemistry*
Grant Support
ID/Acronym/Agency:
GM087620/GM/NIGMS NIH HHS; P01 HL107151/HL/NHLBI NIH HHS; P01L107151//PHS HHS; R01 AI050143/AI/NIAID NIH HHS; R01 CA138891/CA/NCI NIH HHS; R01 GM087620/GM/NIGMS NIH HHS; R01AI050143/AI/NIAID NIH HHS; T32 AI007606/AI/NIAID NIH HHS; T32AI007606/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Sialic Acid Binding Immunoglobulin-like Lectins; 131-48-6/N-Acetylneuraminic Acid
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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