Document Detail


Cleveland clinic CorAide blood pump circulatory support without anticoagulation.
MedLine Citation:
PMID:  12058998     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Cleveland Clinic CorAide left ventricular assist system consists of a permanently implantable centrifugal pump in which the rotating assembly is completely suspended and noncontacting. A series of chronic animal in vivo studies were conducted to evaluate the biologic effects of CorAide circulatory support without the use of anticoagulation therapy. The CorAide pump was implanted in six calves (five calves for 21 to 32 days and one calf for 95 days). The first five calves received intravenous heparin during the early postoperative periods (2-7 days). Heparin administration was then discontinued and no other anticoagulant drugs were used for the duration of the experiments. The last calf did not receive any anticoagulant except for a bolus dose of heparin (200 U/kg) during surgery. Hemodynamics were stable in all six calves, with a mean pump flow of 5.6+/-1.2 L/min and mean arterial pressure of 100+/-4 mm Hg. The blood pump surfaces were clean of thrombus in all six calves. Significant findings at autopsy were limited to one case of renal infarction. There was no incidence of mechanical failure, bleeding, or device infection. The CorAide pump can be safely run with minimal or no anticoagulant therapy.
Authors:
Yoshie Ochiai; Leonard A R Golding; Alex L Massiello; Alexander L Medvedev; David J Horvath; Renee L Gerhart; Ji-Feng Chen; Alexandra Y Krogulecki; Masami Takagaki; Kazuyoshi Doi; Michael W Howard; Kiyotaka Fukamachi
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  ASAIO journal (American Society for Artificial Internal Organs : 1992)     Volume:  48     ISSN:  1058-2916     ISO Abbreviation:  ASAIO J.     Publication Date:    2002 May-Jun
Date Detail:
Created Date:  2002-06-12     Completed Date:  2002-11-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9204109     Medline TA:  ASAIO J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  249-52     Citation Subset:  IM    
Affiliation:
Department of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic Foundation, Ohio 44195, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anticoagulants / pharmacology*
Cattle
Heart-Assist Devices*
Hemodynamics
Heparin / pharmacology
Humans
Grant Support
ID/Acronym/Agency:
N01-HV-58155/HV/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Anticoagulants; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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