Document Detail

Cleft lip and palate versus cleft lip only: are they distinct defects?
MedLine Citation:
PMID:  16076837     Owner:  NLM     Status:  MEDLINE    
Cleft lip defects are usually regarded as a single entity, with the assumption that an accompanying cleft palate represents the more severe form. The authors linked data from the Medical Birth Registry of Norway with medical records from two centralized centers to provide a population-based data set. They assessed the distribution of cleft lip only and cleft lip with cleft palate by covariate. Among 1.8 million Norwegian livebirths between 1967 and 1998, there were 1,572 cases of cleft lip with cleft palate and 1,122 cases with cleft lip only. Seventeen percent of those with cleft lip and palate had another defect compared with 9% of those with cleft lip only. For boys, the risk was greater for cleft lip and palate than for cleft lip only (odds ratio=2.4 vs. 1.8, p<0.001 for difference). The risk of cleft lip only, but not of cleft lip and palate, was increased for twins (odds ratio=1.6 vs. 1.1, p=0.11) and infants whose parents were first cousins (odds ratio=2.7 vs. 0.7, p=0.07). Although cleft lip with cleft palate may simply represent a more severe form of the defect, epidemiologic assessments of cleft lip should, when possible, include separate analyses of these two groups.
Emily W Harville; Allen J Wilcox; Rolv Terje Lie; Hallvard Vindenes; Frank Abyholm
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Publication Detail:
Type:  Journal Article     Date:  2005-08-02
Journal Detail:
Title:  American journal of epidemiology     Volume:  162     ISSN:  0002-9262     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-08-19     Completed Date:  2005-10-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  448-53     Citation Subset:  IM    
Department of Epidemiology, University of North Carolina-Chapel Hill, Chapel Hill, NC 27599-7435, USA.
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MeSH Terms
Abnormalities, Multiple / epidemiology
Chi-Square Distribution
Cleft Lip / epidemiology*
Cleft Palate / epidemiology*
Infant, Newborn
Infant, Premature
Logistic Models
Norway / epidemiology
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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