Document Detail

Cleft lip and palate: an adverse pregnancy outcome due to undiagnosed maternal and paternal coeliac disease.
MedLine Citation:
PMID:  20188484     Owner:  NLM     Status:  MEDLINE    
Development of orofacial component involves a complex series of events. Any insult to this significant event can lead to various orofacial cleft defects. The main categories among orofacial clefts are isolated cleft palate and cleft lip with or without cleft palate. There have been many factors implicated in the development of the anomaly. The environmental factors which contribute and the genes which predispose to the condition remain obscure despite decades of research. Though it is generally agreed that folic acid deficiency is a contributory factor for non-syndromic cleft lip and palate, fewer concerns are directed towards the role for maternal/paternal nutrition in orofacial cleft origin. However, previously undescribed, here we consider the potential influence of maternal and paternal coeliac disease on the etiology of non-syndromic cleft lip and palate as an unfavorable pregnancy outcome. We postulated this relationship based on our observation, study and an empirical survey, and could be due either to (I) folic acid mal absorption (II) a genetically mediated genomic imprinting system.
Gururaj Arakeri; Veena Arali; Peter A Brennan
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Publication Detail:
Type:  Journal Article     Date:  2010-02-25
Journal Detail:
Title:  Medical hypotheses     Volume:  75     ISSN:  1532-2777     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-02     Completed Date:  2010-09-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  United States    
Other Details:
Languages:  eng     Pagination:  93-8     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Peter Brennan's Indian academy of craniofacial researches (PBIACR), Shahapur, Karnataka, India.
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MeSH Terms
Celiac Disease / complications*
Cleft Lip / complications*
Cleft Palate / complications*
Folic Acid / metabolism
Pregnancy Outcome*
Reg. No./Substance:
59-30-3/Folic Acid

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