Document Detail


Cleft lip and palate: an adverse pregnancy outcome due to undiagnosed maternal and paternal coeliac disease.
MedLine Citation:
PMID:  20188484     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Development of orofacial component involves a complex series of events. Any insult to this significant event can lead to various orofacial cleft defects. The main categories among orofacial clefts are isolated cleft palate and cleft lip with or without cleft palate. There have been many factors implicated in the development of the anomaly. The environmental factors which contribute and the genes which predispose to the condition remain obscure despite decades of research. Though it is generally agreed that folic acid deficiency is a contributory factor for non-syndromic cleft lip and palate, fewer concerns are directed towards the role for maternal/paternal nutrition in orofacial cleft origin. However, previously undescribed, here we consider the potential influence of maternal and paternal coeliac disease on the etiology of non-syndromic cleft lip and palate as an unfavorable pregnancy outcome. We postulated this relationship based on our observation, study and an empirical survey, and could be due either to (I) folic acid mal absorption (II) a genetically mediated genomic imprinting system.
Authors:
Gururaj Arakeri; Veena Arali; Peter A Brennan
Related Documents :
25490554 - Reference intervals for n-terminal pro-b-type natriuretic peptide in amniotic fluid bet...
642484 - Acquisition of comprehension of the verb phrase anaphora construction.
18640784 - Cerebral white matter in early puberty is associated with luteinizing hormone concentra...
23716894 - Dexmedetomidine modifies uterine contractions in pregnancy terms of rats.
23507134 - Rapid policy change to single-embryo transfer while maintaining pregnancy rates per ini...
2026454 - The partially purified pre-implantation suppressor factor may be one of several factors...
Publication Detail:
Type:  Journal Article     Date:  2010-02-25
Journal Detail:
Title:  Medical hypotheses     Volume:  75     ISSN:  1532-2777     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-02     Completed Date:  2010-09-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  United States    
Other Details:
Languages:  eng     Pagination:  93-8     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Peter Brennan's Indian academy of craniofacial researches (PBIACR), Shahapur, Karnataka, India. gururaj.arakeri@gmail.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Celiac Disease / complications*
Cleft Lip / complications*
Cleft Palate / complications*
Female
Folic Acid / metabolism
Humans
Male
Pregnancy
Pregnancy Outcome*
Chemical
Reg. No./Substance:
59-30-3/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A parallel process model of the development of positive smoking expectancies and smoking behavior du...
Next Document:  Diphenyl diselenide behaves differently than ebselen under different pH media in rat's liver prepara...