| Cleft lip and palate associated with other malformations in a neotropical primate (Saimiri ustus). | |
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MedLine Citation:
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PMID: 20587169 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Cleft lip (with or without cleft palate) has been documented in several species of nonhuman primates, which in general are susceptible at similar doses and stages of gestation to the same teratogens as humans. Cleft lip can be unilateral or bilateral, isolated, syndromic, familial, or genetic. Here we report the first case of syndromic cleft lip and palate in a male bare-eared squirrel monkey (Saimiri ustus). Associated with the orofacial clefts, the monkey manifested absence of bones, malformation of vertebrae L3, only 4 fingers in each hand, and shortening of tendons leading to inflection of the hands and fingers. Previous reports describing cleft lip and palate in other squirrel monkeys (Saimiri sciureus) in other breeding units have suggested consanguineous mating as a possible cause. Although the etiology in the case we present is unknown, we discuss factors associated with orofacial clefts in humans and various nonhuman primates. |
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Authors:
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Beatriz Goldschmidt; Claudia Aa Lopes; Marina Moura; Denise M Nogueira; Miguel Ab Gonçalves; Daniele M Fasano; Marcia Cr Andrade; Laine Wf Nascimento; Antonio M Marinho |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the American Association for Laboratory Animal Science : JAALAS Volume: 49 ISSN: 1559-6109 ISO Abbreviation: J. Am. Assoc. Lab. Anim. Sci. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-06-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101269489 Medline TA: J Am Assoc Lab Anim Sci Country: United States |
Other Details:
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Languages: eng Pagination: 357-60 Citation Subset: IM |
Affiliation:
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Center for Laboratory Animal Breeding, Department of Primatology, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. bibi@fiocruz.br |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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