| Cleavage of nucleolin and AgNOR proteins during apoptosis induced by anticancer drugs in human salivary gland cells. | |
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MedLine Citation:
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PMID: 16091115 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: To investigate the behavior of nuclear proteins in apoptosis induced by anticancer drugs in cultured human salivary gland (HSG) cells. METHODS: Dynamic alternations of nucleolin and argyrophilic nucleolar organizer region (AgNOR) proteins in anticancer drug-induced apoptosis of HSG cells and in a cell-free apoptotic system were examined using Western blot analysis and immunocytochemical method. RESULTS: The 110-kDa form of nucleolin and AgNOR protein decreased and the 80- and 95-kDa forms appeared during apoptosis in HSG cells and in a cell-free apoptotic system. In addition, the induction of DNA ladder formation coincided with the appearance of alternation of nucleolin and AgNOR proteins in a cell-free apoptosis. Nucleolin diffusely spread out into the nuclear material in the apoptotic body of HSG cells. CONCLUSIONS: The present results indicate that alternations of nucleolin and AgNOR proteins are associated with the induction of DNA fragmentation and the final active phase of apoptosis induced by anticancer drugs in malignant salivary gland cells. |
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Authors:
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S Kito; Y Morimoto; T Tanaka; T Haneji; T Ohba |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology Volume: 34 ISSN: 0904-2512 ISO Abbreviation: J. Oral Pathol. Med. Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-08-10 Completed Date: 2005-09-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8911934 Medline TA: J Oral Pathol Med Country: Denmark |
Other Details:
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Languages: eng Pagination: 478-85 Citation Subset: D; IM |
Affiliation:
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Department of Dental Radiology, Kyushu Dental College, 2-6-1 Manazuru, Kokurakita-ku, Kitakyushu 803-8580, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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pharmacology* Apoptosis / drug effects*, physiology* Cell-Free System Cells, Cultured Cisplatin / pharmacology DNA Fragmentation Epithelial Cells / drug effects Humans Mitomycin / pharmacology Nuclear Proteins / drug effects*, metabolism Nucleolus Organizer Region / chemistry, drug effects, metabolism Phosphoproteins / drug effects, metabolism RNA-Binding Proteins / drug effects, metabolism Salivary Glands / cytology, drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Nuclear Proteins; 0/Phosphoproteins; 0/RNA-Binding Proteins; 0/nucleolin; 15663-27-1/Cisplatin; 50-07-7/Mitomycin |
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