| Cleavage of the hormone human chorionic gonadotropin, by the Type 1 IgA1 protease of Neisseria gonorrhoeae, and its implications. | |
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MedLine Citation:
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PMID: 11550129 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The hormone human chorionic gonadotropin (hCG) serves to maintain the fetus during early pregnancy and regulate the onset of labor in late pregnancy. hCG also prevents Neisseria gonorrhoeae from developing invasive characteristics. Part of the beta subunit of hCG has an amino acid sequence similar to that of the hinge of human IgA1, which is the site of action of IgA1 proteases. This study examined the sensitivity of hCG to gonococcal IgA1 proteases, by means of autoradiography, immunoblotting, and RIA. hCG was cleaved in the beta subunit by the type 1 but not the type 2 IgA1 proteases of N. gonorrhoeae. hCG cleavage by gonococcal IgA1 proteases in vivo may increase the invasiveness of the pathogen and destroy its natural biologic activity, with major consequences for the fetus and the pregnancy. |
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Authors:
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B W Senior; W W Stewart; C Galloway; M A Kerr |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2001-08-29 |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 184 ISSN: 0022-1899 ISO Abbreviation: J. Infect. Dis. Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2001-09-10 Completed Date: 2001-11-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: 922-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Molecular and Cellular Pathology, University of Dundee Medical School, Ninewells Hospital, Dundee DD1 9SY, Scotland. b.w.senior@dundee.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Autoradiography Chorionic Gonadotropin / metabolism* Chorionic Gonadotropin, beta Subunit, Human / chemistry, metabolism Humans Immunoblotting Immunoglobulin A / chemistry, metabolism Molecular Sequence Data Neisseria gonorrhoeae / enzymology* Peptide Fragments / chemistry Serine Endopeptidases / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin; 0/Chorionic Gonadotropin, beta Subunit, Human; 0/Immunoglobulin A; 0/Peptide Fragments; EC 3.4.21.-/Serine Endopeptidases; EC 3.4.21.72/IgA-specific serine endopeptidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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