Document Detail

Cleavage of the hormone human chorionic gonadotropin, by the Type 1 IgA1 protease of Neisseria gonorrhoeae, and its implications.
MedLine Citation:
PMID:  11550129     Owner:  NLM     Status:  MEDLINE    
The hormone human chorionic gonadotropin (hCG) serves to maintain the fetus during early pregnancy and regulate the onset of labor in late pregnancy. hCG also prevents Neisseria gonorrhoeae from developing invasive characteristics. Part of the beta subunit of hCG has an amino acid sequence similar to that of the hinge of human IgA1, which is the site of action of IgA1 proteases. This study examined the sensitivity of hCG to gonococcal IgA1 proteases, by means of autoradiography, immunoblotting, and RIA. hCG was cleaved in the beta subunit by the type 1 but not the type 2 IgA1 proteases of N. gonorrhoeae. hCG cleavage by gonococcal IgA1 proteases in vivo may increase the invasiveness of the pathogen and destroy its natural biologic activity, with major consequences for the fetus and the pregnancy.
B W Senior; W W Stewart; C Galloway; M A Kerr
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2001-08-29
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  184     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-09-10     Completed Date:  2001-11-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  922-5     Citation Subset:  AIM; IM    
Department of Molecular and Cellular Pathology, University of Dundee Medical School, Ninewells Hospital, Dundee DD1 9SY, Scotland.
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MeSH Terms
Amino Acid Sequence
Chorionic Gonadotropin / metabolism*
Chorionic Gonadotropin, beta Subunit, Human / chemistry,  metabolism
Immunoglobulin A / chemistry,  metabolism
Molecular Sequence Data
Neisseria gonorrhoeae / enzymology*
Peptide Fragments / chemistry
Serine Endopeptidases / metabolism*
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Chorionic Gonadotropin, beta Subunit, Human; 0/Immunoglobulin A; 0/Peptide Fragments; EC 3.4.21.-/Serine Endopeptidases; EC serine endopeptidase

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