| Cleavage of Carbon-Carbon Bonds through the Mild Release of Trifluoroacetate: Generation of α,α-Difluoroenolates for Aldol Reactions. | |
| | |
MedLine Citation:
|
PMID: 21443226 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The selective cleavage of carbon-carbon bonds is a significant challenge in synthetic chemistry, yet this strategy can be a powerful way to generate reactive intermediates. We have discovered that, through the facile release of trifluoroacetate which occurs by C-C bond scission, difluoroenolates can be generated under very mild reaction conditions. Unlike existing reactions, this method is not limited to a small group of fluorinated building blocks. We have applied this process to the aldol reaction to install difluoromethylene groups. |
| | |
Authors:
|
Changho Han; Eun Hoo Kim; David A Colby |
Related Documents
:
|
21202736 - Dibromido{2-[2-(piperidinium-1-yl)ethyl-imino-meth-yl]phenolato}zinc(ii) monohydrate. 21245536 - X-ray and neutron protein crystallographic analysis of the trypsin-bpti complex. 21200616 - Substitutional disorder in a hypervalent diorganotin(iv) dihalide. 21202836 - 2-chloro-n-(4-fluoro-phen-yl)acetamide. 3978086 - Tetrahydrobiopterin analogues: solution conformations of 6-methyltetrahydropterin, 7-me... 21588416 - N-(4-chloro-benzyl-idene)-3,4-dimethyl-isoxazol-5-amine. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-28 |
Journal Detail:
|
Title: Journal of the American Chemical Society Volume: - ISSN: 1520-5126 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-29 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7503056 Medline TA: J Am Chem Soc Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Medicinal Chemistry and Molecular Pharmacology and ‡Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Mechanistic Insights into the Decomposition of Fructose to Hydroxy Methyl Furfural in Neutral and Ac...
Next Document: Cluster Formation in Polyelectrolyte-Micelle Complex Coacervation.