| Clearance of some quaternary amines from the spinal subarachnoid space. | |
| | |
MedLine Citation:
|
PMID: 1146579 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The spinal subarachnoid space was perfused with artificial cerebrospinal fluid (CSF) from the low lumbar level to the middle thoracic level or to the cisterna magna in anesthetized rabbits. 3-H-choline, 3-H-methyl-atropine or 3-H-decamethonium with carrier in different concentrations was added to the perfusate together with 14-C-inulin, the latter serving as a marker of the dilution of the perfusate by original CSF. Choline was eliminated from the perfusate partly by a saturable mechanism probably by an uptake into the spinal cord. About 15 per cent of the radioactivity of the choline infused was recovered from the spinal cord mainly as phosphorylcholine, betaine, and phospholipids. Amphetamine decreased the elimination of choline from ventriculocisternal perfusates and partly inhibited the uptake of choline in rabbit choroid plexus in vitro. In contrast, amphetamine did not influence the saturable elimination of choline in the lumbothoracic perfusion. Neither methylatropine nor decamethonium was eliminated from the perfusate by a saturable mechanism in the lumbothoracic perfusions. However, in perfusions including the cisterna magna methylatropine was partly eliminated by such a mechanism. The concentration of radioactivity in fourth ventricular choroid plexa suggested this structure to be responsible for the saturable part of the elimination. In conclusion, there is no active removal of quaternary amines in general from spinal CSF like the choroid plexus mediated clearance from ventricular CSF. |
| | |
Authors:
|
S M Aquilonius; B Winbladh; S Zillén |
Related Documents
:
|
6977669 - Recording of pulmonary afferent activities from receptors in the perfused lung preparat... 9127679 - Increased intraluminal pressure induces dna synthesis and c-fos expression in perfused ... 2183269 - Prediction of postoperative loss of lung function in patients with malignant lung mass.... 6727389 - Improved tissue perfusion during pressure-regulated hyperthermic regional isolated perf... 6274589 - Reversible ventilation and perfusion abnormalities in unilateral obstructed lung. 9806679 - Thoracoscopic interruption of patent ductus arteriosus compromises cardiopulmonary func... 15242429 - Pulmonary gas distribution during ventilation with different inspiratory flow patterns ... 17601389 - New treatment options for hypertension during acute ischemic or hemorrhagic stroke. 16840739 - Lung volume recruitment after surfactant administration modifies spatial distribution o... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Acta physiologica Scandinavica Volume: 93 ISSN: 0001-6772 ISO Abbreviation: Acta Physiol. Scand. Publication Date: 1975 Mar |
Date Detail:
|
Created Date: 1975-09-29 Completed Date: 1975-09-29 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0370362 Medline TA: Acta Physiol Scand Country: SWEDEN |
Other Details:
|
Languages: eng Pagination: 378-84 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Atropine / metabolism* Choline / metabolism* Decamethonium Compounds / metabolism* Inulin / metabolism Rabbits Spinal Cord / metabolism Subarachnoid Space / metabolism* Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Decamethonium Compounds; 51-55-8/Atropine; 62-49-7/Choline; 9005-80-5/Inulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of myocardial infarction on adrenergic nerves of the rat heart muscle, a histochemical study...
Next Document: The metabolism of acetate in the perfused hind-quarter of the rat.